193689-60-0

Upstream product

• 421-83-0 trifluoromethane sulfonyl chloride 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 358-23-6 trifluoromethylsulfonic anhydride 

Downstream Products

• 193689-56-4 {[2-(3,4-Dimethoxy-phenyl)-ethyl]-trifluoromethanesulfonyl-amino}-acetic acid ethyl ester 
• 193689-54-2 2-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-trifluoromethanesulfonyl-amino}-propionic acid ethyl ester 
• 193689-43-9 2-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-trifluoromethanesulfonyl-amino}-propionic acid 
• 193689-45-1 {[2-(3,4-Dimethoxy-phenyl)-ethyl]-trifluoromethanesulfonyl-amino}-acetic acid 

Relevant academic research and scientific papers

Palladium-Catalyzed [5 + 2] Heteroannulation of Phenethylamides with 1,3-Dienes to Dopaminergic 3-Benzazepines

Phenethyltriflamides react with 1,3-dienes upon treatment with a catalytic amount of Pd(OAc)2 and Cu(OAc)2/O2 as oxidant to afford chemo-, regio- A nd diastereoselectively 2,3,4,5-tetrahydro-1H-benzo[d]azepines (3-benzazepine derivatives) in good to excellent yields. A DFT study of the [5 + 2] heteroannulation suggests a mechanistic pathway starting with formation of the six-membered palladacycle cis-PdX2L2 via a CMD process followed by ??2 coordination and insertion of the 1,3-diene unit in a diastereoselective manner.

Use of the triflamide group for friedel-crafts acylation of N-(β-phenethyl)amino acids to 3-benzazepine derivatives

Triflamides of N-(β-phenethyl)amino acids (1) were treated with P2O5 under the Friedel-Crafts acylation conditions to give the 3-benzazepines in good yields. N-(β-Phenethyl)-N-triflylvaline (1f) and phenylglycine (1g) were efficientl