19371-91-6

Basic information

• Product Name: 2-[(2-FLUOROPHENYL)METHYLENE]-1H-INDENE-1,3(2H)-DIONE
• Synonyms: 2-[(2-FLUOROPHENYL)METHYLENE]-1H-INDENE-1,3(2H)-DIONE
• CAS NO: 19371-91-6
• Molecular Formula: C₁₆H₉FO₂
• Molecular Weight: 252.24
• Mol File: 19371-91-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[(2-FLUOROPHENYL)METHYLENE]-1H-INDENE-1,3(2H)-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(2-FLUOROPHENYL)METHYLENE]-1H-INDENE-1,3(2H)-DIONE(19371-91-6)
• EPA Substance Registry System: 2-[(2-FLUOROPHENYL)METHYLENE]-1H-INDENE-1,3(2H)-DIONE(19371-91-6)

Safety Data

• Hazardous Substances Data: 19371-91-6(Hazardous Substances Data)

Usage

Physical state

Yellow crystalline powder

Usage

Synthesis of various pharmaceuticals and organic compounds

Chemical properties

Unique due to the phenylmethylene group attached to the indene-1,3-dione core

Applications

Drug development, materials science, organic synthesis reagent, building block for complex organic molecules

Importance

Intermediate in the production of fine chemicals, focus of ongoing research in chemical and pharmaceutical industries.

Upstream product

• 606-23-5 1H-indene-1,3(2H)-dione 
• 446-52-6 2-Fluorobenzaldehyde 

Downstream Products

• 791-28-6 Triphenylphosphine oxide 

Relevant articles and documents

Phosphine-Catalyzed Cascade Michael Addition/[4+2] Cycloaddition Reaction of Allenoates and 2-Arylidene-1,3-indanediones

The phosphine-catalyzed cascade Michael addition/[4+2] cycloaddition reaction of tetrahydrobenzofuranone-derived allenoates and 2-arylidene-1,3-indanediones has been reported, affording spirocyclic 1,3-indanedione derivatives in moderate to high yields wi

Chemo- and Diastereoselective Construction of Indenopyrazolines via a Cascade aza-Michael/Aldol Annulation of Huisgen Zwitterions with 2-Arylideneindane-1,3-diones

A cascade aza-Michael/Aldol annulation of 2-arylideneindane-1,3-diones with in situ generated Huisgen zwitterions has been developed. This reaction afforded the desired products in moderate to good yields (up to 87%) with excellent chemo- and diastereoselectivity (up to 20:1). This strategy allows facile diastereoselective preparation of biologically important indenopyrazoline derivatives containing two contiguous chiral centers including a quaternary stereogenic center. (Figure presented.).