193738-53-3Relevant academic research and scientific papers
Benzofuran derivatives as ET(A)-selective, non-peptide endothelin antagonists
Kaltenbronn,Quin III,Reisdorph,Klutchko,Reynolds,Welch,Flynn,Doherty
, p. 425 - 431 (2007/10/03)
The synthesis and SAR relationships of a series of 4-benzyloxy-3-methylbenzofuran-2-carboxylic acids are described. Compounds from this series show 2- to 16-fold selective binding to the ET(A) receptor in the micromolar range, and two compounds from this series (32 and 40) were demonstrated to exhibit ET(A) antagonist activity.
