193743-93-0

Basic information

• Product Name: 6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXAMIDE
• Synonyms: 6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXAMIDE
• CAS NO: 193743-93-0
• Molecular Formula: C7H5ClN4O
• Molecular Weight: 196.6
• Mol File: 193743-93-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.75±0.1 g/cm3(Predicted)
• PKA: 11.36±0.50(Predicted)
• CAS DataBase Reference: 6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXAMIDE(193743-93-0)
• EPA Substance Registry System: 6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXAMIDE(193743-93-0)

Safety Data

• Hazardous Substances Data: 193743-93-0(Hazardous Substances Data)

Usage

Structure

Pyridazine derivative with a chlorine atom and an imidazole ring

Pharmaceutical importance

Used in the development of drugs and medications

Biological activity

Can interact with specific targets in the body

Value in medicinal chemistry

Valuable tool in research and development of pharmaceuticals and therapeutic agents

Upstream product

• 64067-99-8 ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate 

Relevant articles and documents

Research on heterocyclic compounds. XXXVIII. Synthesis and pharmacological activity of imidazo[1,2-b]pyridazine-2-carboxylic derivatives

A series of imidazo[1,2-b]pyridazine-2-carboxylic acids, esters and amides was synthesized and tested for antiinflammatory, analgesic and ulcerogenic activities. The ethyl esters were prepared by cyclocondensation of some 3-aminopyridazines with ethyl bromopyruvate, followed by hydrolysis or ammonolysis in order to obtain the corresponding acids and amides. The inhibitory activity on the carrageenaninduced edema in the rat paw and on writhes induced by acetic acid in mice was evaluated, as well as the ulcerogenic action on the rat gastric mucosa. The pharmacological activity was discussed in terms of structure-activity relationships. In particular, the analgestic activity shown by these carboxylic derivatives was compared with that found in other series of imidazo[1,2-b]pyridazine analogues previously examined.