193747-17-0

Basic information

• Product Name: 1H-Pyrazole-4-carboxaldehyde, 5-(1,1-dimethylethyl)-1-phenyl-
• CAS NO: 193747-17-0
• Molecular Formula: C14H16N2O
• Molecular Weight: 228.294
• Mol File: 193747-17-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole-4-carboxaldehyde, 5-(1,1-dimethylethyl)-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-4-carboxaldehyde, 5-(1,1-dimethylethyl)-1-phenyl-(193747-17-0)
• EPA Substance Registry System: 1H-Pyrazole-4-carboxaldehyde, 5-(1,1-dimethylethyl)-1-phenyl-(193747-17-0)

Safety Data

• Hazardous Substances Data: 193747-17-0(Hazardous Substances Data)

Upstream product

• 153863-40-2 (5-tert-Butyl-1-phenyl-1H-pyrazol-4-yl)-methanol 

Downstream Products

• 193747-22-7 (5-tert-Butyl-1-phenyl-1H-pyrazol-4-yl)-phenyl-methanol 
• 296269-57-3 1-(5-tert-butyl-1-phenyl-1H-pyrazol-4-yl)-4-piperidin-1-yl-butan-1-ol 

Relevant articles and documents

ω-Dialkylaminoalkyl Ethers of Phenyl-(5-substituted 1-phenyl-1H-pyrazol-4-yl)methanols with Analgesic and Anti-inflammatory Activity

A series of carbinols 3a-f was prepared starting from methanols 1a-f via oxidation with pyridinium chlorochromate to aldehydes 2a-f, followed by a Grignard reaction of the latter. Reaction of 3a-f with ω-chloroalkyldialkylamine hydrochlorides afforded a series of aminoether derivatives 4g-t. Compounds 4i,m-p,s showed a good analgesic activity in the acetic acid writhing test in mice. Moreover, compounds 4h,l,s exhibited a moderate anti-inflammatory activity in the carrageenan-induced edema assay in rats.