193755-91-8Relevant academic research and scientific papers
Construction of Quaternary Carbon Center by Catalytic Asymmetric Alkylation of 3-Arylpiperidin-2-ones Under Phase-Transfer Conditions
Inukai, Tomoaki,Kano, Taichi,Maruoka, Keiji
, p. 2211 - 2214 (2020)
A highly enantioselective synthesis of δ-lactams having a chiral quaternary carbon center at the α-position has been developed through an asymmetric alkylation of 3-arylpiperidin-2-ones under phase-transfer conditions. In this transformation, a 2,2-diarylvinyl group on the δ-lactam nitrogen atom plays a crucial role as a novel protecting group and an achiral auxiliary for improving both yield and enantioselectivity of the reaction.
3-Azetidinylalkylpiperidines or -pyrrolidines as tachykinin antagonists
-
, (2008/06/13)
The present invention provides compounds of formula (I) and the pharmaceutically acceptable salts thereof. Such compounds and salts are tachykinin antagonists.
