193806-49-4

Usage

Uses

Used in Pharmaceutical Industry:
Carbamic acid, N-[2-(2-hydroxyethyl)phenyl]-,1,1-dimethylethyl ester is used as an antitussive agent for the treatment of coughs. It is incorporated into over-the-counter cough and cold medications due to its effectiveness in depressing the cough reflex, offering relief to patients experiencing coughing.
As a cough suppressant, carbetapentane is utilized for its ability to alleviate the discomfort and distress associated with coughing, making it a valuable component in various formulations intended to treat respiratory conditions characterized by persistent coughing. It is generally considered safe and effective when used as directed, under the guidance of a healthcare professional, to minimize potential side effects and interactions with other medications.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 5339-85-5 2-aminophenethyl alcohol 
• 88-72-2 1-methyl-2-nitrobenzene 
• 15121-84-3 2-nitro-benzeneethanol 

Downstream Products

• 518285-17-1 tert-Butyl 2-(2-bromoethyl)phenylcarbamate 
• 760175-28-8 {2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-carbamic acid tert-butyl ester 
• 904325-39-9 2-{2-[N-benzyl-N-(tert-butyloxycarbonyl)amino]phenyl}ethanol 
• 193806-62-1 2-Allyl-2-[2-(2-tert-butoxycarbonylamino-phenyl)-ethylsulfanylcarbonylmethyl]-malonic acid diethyl ester 
• 193806-60-9 2-Allyl-4-nitro-thiobenzoic acid S-[2-(2-tert-butoxycarbonylamino-phenyl)-ethyl] ester 
• 193806-57-4 2-(2-Methyl-allyloxy)-thiobenzoic acid S-[2-(2-tert-butoxycarbonylamino-phenyl)-ethyl] ester 
• 193806-58-5 2-Prop-2-ynyloxy-thiobenzoic acid S-[2-(2-tert-butoxycarbonylamino-phenyl)-ethyl] ester 
• 193806-61-0 2-Allyl-5-methoxy-thiobenzoic acid S-[2-(2-tert-butoxycarbonylamino-phenyl)-ethyl] ester 
• 193806-56-3 2-Allyloxy-thiobenzoic acid S-[2-(2-tert-butoxycarbonylamino-phenyl)-ethyl] ester 
• 193806-59-6 2-Allyl-thiobenzoic acid S-[2-(2-tert-butoxycarbonylamino-phenyl)-ethyl] ester 
• 193806-51-8 Thioacetic acid S-[2-(2-tert-butoxycarbonylamino-phenyl)-ethyl] ester 

Relevant academic research and scientific papers

NOVEL 4-(2FUROYL)AMINOPIPERIDINES, INTERMEDIATES IN SYNTHESIZING THE SAME,PROCESS FOR PRODUCING THE SAME AND MEDICINAL USE OF THE SAME

There are provided novel 4-(2-furoyl)aminopiperidines represented by the general formula (I), their synthetic intermediates, processes for their preparation and medicaments containing them. In the above formula, X is CH or N, and Y is a group of the following general formula (II), formula (II-a) or formula (III): wherein a, b and c are each an integer of 0-6; Z is CH2 or NH; W is O or S; T is O or N-R15 wherein R15 is H, a C1-C6 alkyl group, a benzyl group or a phenethyl group; and R1 is H, a C1-C6 alkoxycarbonyl group, a benzyloxycarbonyl group, or the like.The 4-(2-furoyl) aminopiperidine derivatives according to this invention possess opioid μ antagonistic activity and are useful for the treatment or prevention of side effects which are caused by μ receptors agonist and which are selected from constipation, nausea/emesis or itch, or for the treatment or prevention of idiopathic constipation, postoperative ileus, paralytic ileus, irritable bowel syndrome or chronic pruritus.

Synthesis of aziridinomitosenes through base-catalyzed conjugate addition

Synthesis of an aziridinomitosene core structure that relies on a facile tertiary-amine base-catalyzed azide conjugate addition is reported. Straightforward derivatization of the conjugate addition product affords the desired mitomycin ring system. Initial catalyst screens have identified peptides that afford the product with modest enantioselectivities.

Radical ring closures of 4-isocyanato carbon-centered radicals

The 2-(2-isocyanatophenyl)ethyl radical was generated from the corresponding bromide with tributyltin and tris(trimethylsilyl)silyl radicals and shown to ring close in the 6-endo-mode to afford 3,4-dihydro-1H-quinolin-2-one as the major product. Cyclization in the 5-exo-mode to produce 2,3-dihydroindole-1-carbaldehyde, after hydrogen abstraction, was a minor reaction. Rate constants for the two processes were estimated and compared with reaction enthalpies computed by the DFT method.

Generation and Cyclization of Acyl Radicals from Thiol Esters under Nonreducing, Tin-Free Conditions

The preparation of 2-(2-((tert-butyloxycarbonyl)amino)phenyl)ethyl mercaptan from 2-(2-aminophenyl)ethanol is described. This thiol is condensed with a series of suitably unsaturated carboxylic acids to give a series of thiol esters. The Boc group is remo