193819-51-1Relevant articles and documents
Hit-to-lead optimization of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of KDR kinase inhibitors
Dinges, Juergen,Akritopoulou-Zanze, Irini,Arnold, Lee D.,Barlozzari, Teresa,Bousquet, Peter F.,Cunha, George A.,Ericsson, Anna M.,Iwasaki, Nobuhiko,Michaelides, Michael R.,Ogawa, Nobuo,Phelan, Kathleen M.,Rafferty, Paul,Sowin, Thomas J.,Stewart, Kent D.,Tokuyama, Ryukou,Xia, Zhiren,Zhang, Henry Q.
, p. 4371 - 4375 (2007/10/03)
A series of 1,4-dihydroindeno[1,2-c]pyrazoles was prepared and evaluated for their enzymatic inhibition of KDR kinase. Computer modeling studies revealed the importance of attaching a basic side chain in predicting the binding mode of those compounds. Fur