193882-67-6

Basic information

• Product Name: methyl 2-ethoxy-5-iodo-benzoate
• CAS NO: 193882-67-6
• Molecular Formula: C₁₀H₁₁IO₃
• Molecular Weight: 306.097
• Mol File: 193882-67-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 343.405°C at 760 mmHg
• Flash Point: 161.486°C
• Density: 1.612g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: methyl 2-ethoxy-5-iodo-benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-ethoxy-5-iodo-benzoate(193882-67-6)
• EPA Substance Registry System: methyl 2-ethoxy-5-iodo-benzoate(193882-67-6)

Safety Data

• Hazardous Substances Data: 193882-67-6(Hazardous Substances Data)

Upstream product

• 74-96-4 ethyl bromide 
• 4068-75-1 methyl 5-iodosalicylate 

Downstream Products

• 193882-66-5 2-ethoxy-5-iodobenzoic acid 

Relevant articles and documents

Synthesis and 5-HT-3 receptor binding activity of 5-[125I]iodo-2,3-dimethoxy-N-(1-azabicyclo[2.2.2]oct-3-yl]benzamide and its 5-halogen-2-alkoxyl homologues

(S)-5-Iodo-2,3-dimethoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamide (MIZAC) was prepared from 5-iodo-2,3-dimethoxybenzoyl chloride and (S)-3-aminoquinuclidine. [125I]Iodode-stannylation of its corresponding 5-tri-n-butyltin derivative gave [125I]-MIZAC at 1800 Ci/mmol. Binding of [125I]-MIZAC in rat entorhinal cortex revealed a K(D) of 1.37 ± 0.21 nM. A series of racemic 2-O-alkyl derivatives of MIZAC were prepared and 5-HT-3 receptor affinities were determined by inhibition of [125I]-MIZAC binding. Optimal affinity for the receptor was obtained with small, electron-withdrawing substituents in the aromatic 5-position and with bulky substituents in the 3-position. [125I]-MIZAC is a selective radioligand useful for in vitro identification of the 5-HT-3 receptor.