193882-76-7

Basic information

• Product Name: Benzoic acid, 2-(3-fluoropropoxy)-5-iodo-, methyl ester
• CAS NO: 193882-76-7
• Molecular Formula: C11H12FIO3
• Molecular Weight: 338.117
• Mol File: 193882-76-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-(3-fluoropropoxy)-5-iodo-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-(3-fluoropropoxy)-5-iodo-, methyl ester(193882-76-7)
• EPA Substance Registry System: Benzoic acid, 2-(3-fluoropropoxy)-5-iodo-, methyl ester(193882-76-7)

Safety Data

• Hazardous Substances Data: 193882-76-7(Hazardous Substances Data)

Upstream product

• 352-91-0 1-Bromo-3-fluoropropane 
• 4068-75-1 methyl 5-iodosalicylate 

Downstream Products

• 193882-75-6 5-iodo-2-(3-fluoropropoxy)benzoic acid 

Relevant articles and documents

Synthesis and 5-HT-3 receptor binding activity of 5-[125I]iodo-2,3-dimethoxy-N-(1-azabicyclo[2.2.2]oct-3-yl]benzamide and its 5-halogen-2-alkoxyl homologues

(S)-5-Iodo-2,3-dimethoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamide (MIZAC) was prepared from 5-iodo-2,3-dimethoxybenzoyl chloride and (S)-3-aminoquinuclidine. [125I]Iodode-stannylation of its corresponding 5-tri-n-butyltin derivative gave [125I]-MIZAC at 1800 Ci/mmol. Binding of [125I]-MIZAC in rat entorhinal cortex revealed a K(D) of 1.37 ± 0.21 nM. A series of racemic 2-O-alkyl derivatives of MIZAC were prepared and 5-HT-3 receptor affinities were determined by inhibition of [125I]-MIZAC binding. Optimal affinity for the receptor was obtained with small, electron-withdrawing substituents in the aromatic 5-position and with bulky substituents in the 3-position. [125I]-MIZAC is a selective radioligand useful for in vitro identification of the 5-HT-3 receptor.