193885-36-8

Upstream product

• 493-09-4 benzo-1,4-dioxane 
• 215175-90-9 Ethyl 2-(2,3-dihydrobenzo[b][1,4]dioxin-7-yl)propanoate 
• 1026628-22-7 Toluene-4-sulfonic acid 1-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-ethyl ester 
• 131030-47-2 2,3-dihydrobenzo[1,4]dioxin-6-ylhydroxyacetic acid ethyl ester 
• 193885-37-9 2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-oxoacetic acid 
• 177158-18-8 2-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-1-morpholin-4-yl-ethanethione 
• 2879-20-1 1,4-benzodioxan-6-yl methyl ketone 
• 7338-03-6 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethan-1-ol 
• 17253-11-1 2,3-dihydro-1,4-benzodioxin-6-ylacetic acid 
• 74-88-4 methyl iodide 
• 193885-38-0 2-(R,S)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxypropanoic acid 
• 193885-35-7 2-(2,3-dihydro-1,4-benzodioxin-6-yl)propionitrile 

Relevant academic research and scientific papers

SUBSTITUTED AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS

The invention relates to substituted aromatic carboxamide and urea derivatives, to processes for the preparation thereof, to pharmaceutical compositions containing these compounds and also to the use of these compounds for preparing pharmaceutical compositions (formula (I)).

Vanilloid Receptor Ligands, Pharmaceutical Compositions Containing Them, Process for Making Them, and Use Thereof for Treating Pain and Other Conditions

Vanilloid receptor ligand compounds corresponding to formula I: pharmaceutical compositions containing such compounds, a process for producing such compounds, and methods of using such compounds for treating or inhibiting pain and various other disorders or conditions.

Synthesis and anti-inflammatory activity of rac-2-(2,3-dihydro-1,4-benzodioxin)propionic acid and its R and S enantiomers

Racemic (R,S)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)propionic acid (3) has been prepared from 2,3-dihydro-1,4-benzodioxin. R-(-)-Pantolactone has been used as auxiliary for the synthesis of R-3 and S-3. The anti-inflammatory properties of the new carboxylic acids are described and compared with other anti-inflammatory agents. The highest activity is exhibited by compound S-3.