19389-31-2Relevant academic research and scientific papers
Ring Transformation of 3-Hydroxy-1,2,5- and -1,2,4-thiadiazoles and -isothiazoles into Isothiazole , Thiazole and Thiophene Derivatives
Mataka, Shuntaro,Takahashi, Kazufumi,Tashiro, Masashi
, p. 1496 - 1502 (2007/10/02)
Ring transformation of 3-hydroxy-1,2,5-thiadiazole (1), 3-hydroxy-1,2,4-thiadiazole (14), and 3-hydroxyisothiazole (18) by the reaction with acetic anhydride in the presence of DBU afforded isothiazoles 2-5 and 13, thiazoles 15 and 16 and thiophenes 21-25, respectively.The reaction of 1 with propionic anhydride gave isothiazole 13.The formation pathway of the products is mentioned.
