1939-21-5

Usage

Uses

Used in Pharmaceutical Research:
3'-Trifluoromethyl-2-phenylacetanilide is used as a potential analgesic and anti-inflammatory agent for its ability to alleviate pain and reduce inflammation. The trifluoromethyl group and the acetanilide moiety contribute to its pharmacological profile, making it a promising candidate for the development of new drugs in the treatment of pain and inflammation.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 3'-Trifluoromethyl-2-phenylacetanilide is utilized as an important chemical for exploring its structure-activity relationships and optimizing its therapeutic potential. Its unique molecular structure allows researchers to investigate its interactions with biological targets and evaluate its efficacy and safety in preclinical studies, with the aim of advancing it towards clinical trials and eventual pharmaceutical applications.

Upstream product

• 98-16-8 3-trifluoromethylaniline 
• 103-80-0 phenylacetyl chloride 
• 109134-07-8 t-butyl<3-(trifluoromethyl)phenyl>-carbamate 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 103-82-2 phenylacetic acid 
• 103-81-1 Benzeneacetamide 
• 98-15-7 3-chlorotrifluoromethylbenzene 
• 260783-80-0 N,N,N--trimethyl--1--phenylmethanaminium trifluoromethanesulfonate 
• 201230-82-2 carbon monoxide 
• 103-83-3 N,N'-dimethylbenzylamine 
• 401-81-0 m-trifluoromethylphenyl iodide 

Downstream Products

• 96719-12-9 1-(2,4-Dichloro-phenyl)-2-(3-trifluoromethyl-phenyl)-3,4-dihydro-isoquinolinium; iodide 
• 96719-11-8 1-(2-Fluoro-phenyl)-2-(3-trifluoromethyl-phenyl)-3,4-dihydro-isoquinolinium; iodide 
• 96719-10-7 1-Phenyl-2-(3-trifluoromethyl-phenyl)-3,4-dihydro-isoquinolinium; iodide 
• 96718-81-9 2,4-Dichloro-N-phenethyl-N-(3-trifluoromethyl-phenyl)-benzamide 
• 96718-79-5 2-Fluoro-N-phenethyl-N-(3-trifluoromethyl-phenyl)-benzamide 
• 96718-80-8 3-Bromo-N-phenethyl-N-(3-trifluoromethyl-phenyl)-benzamide 
• 96719-45-8 1-(2-Fluoro-phenyl)-2-(3-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-isoquinoline 
• 96718-78-4 N-Phenethyl-N-(3-trifluoromethyl-phenyl)-benzamide 
• 96719-44-7 1-Phenyl-2-(3-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-isoquinoline 
• 96718-70-6 Phenethyl-(3-trifluoromethyl-phenyl)-amine 

Relevant academic research and scientific papers

Compound containing bipyrazole ring, intermediate thereof and application thereof

The invention discloses a compound containing a bipyrazole ring, and an intermediate and application thereof. The invention provides the compound containing a bipyrazole ring, as shown in a formula Iwhich is described in the specification. The compound can be used as a ligand, is high in selectivity, and is suitable for the application range of amide in C-N coupling and the C-C coupling reactionof arylboronic acid and aryl chloride, especially coupling with aryl chloride.

Preparation method of compound containing bipyrazole ring and intermediate thereof

The invention discloses a preparation method of a compound containing a bipyrazole ring and an intermediate of the compound. The preparation method of a bipyrazole ring-containing compound as shown ina formula I comprises the following steps: (1) adding alkali into a mixture of a bipyrazole ring compound as shown in a formula I-1 and a solvent for replacement reaction to obtain a mixed system; and (2) adding an organic phosphorus compound shown as a formula I-2 into the mixed system in the step (1), and carrying out a phosphonation reaction shown in the specification, so as to obtain the bipyrazole ring-containing compound shown as the formula I, wherein R1 and R2 are independently a C1-C6 alkyl group, a C3-C8 cycloalkyl group and a phenyl group, R3 is a C1-C6 alkyl group, and X is halogen. The prepared compound containing a bipyrazole ring can be used as a ligand, and is suitable for the application range of amide in C-N coupling and the C-C coupling reaction of arylboronic acid andaryl chloride.

Catalytic direct amidations in: Tert -butyl acetate using B(OCH2CF3)3

Catalytic direct amidation reactions have been the focus of considerable recent research effort, due to the widespread use of amide formation processes in pharmaceutical synthesis. However, the vast majority of catalytic amidations are performed in non-polar solvents (aromatic hydrocarbons, ethers) which are typically undesirable from a sustainability perspective, and are often poor at solubilising polar carboxylic acid and amine substrates. As a consequence, most catalytic amidation protocols are unsuccessful when applied to polar and/or functionalised substrates of the kind commonly used in medicinal chemistry. In this paper we report a practical and useful catalytic direct amidation reaction using tert-butyl acetate as the reaction solvent. The use of an ester solvent offers improvements in terms of safety and sustainability, but also leads to an improved reaction scope with regard to polar substrates and less nucleophilic anilines, both of which are important components of amides used in medicinal chemistry. An amidation reaction was scaled up to 100 mmol and proceeded with excellent yield and efficiency, with a measured process mass intensity of 8.

Palladium-catalyzed carbonylation of benzylic ammonium salts to amides and esters: Via C-N bond activation

An efficient palladium-catalyzed carbonylation reaction of readily available quaternary ammonium salts with CO is reported for the first time to afford arylacetamides and arylacetic acid esters via benzylic C-N bond cleavage. This protocol features mild reaction conditions under atmospheric pressure of CO, a redox-neutral process without an additional oxidant, and a broad substrate scope for various kinds of amines, alcohols and phenols.

Metal-free hydration of ynamides: Convenient approach to amides

The trifluoroacetic acid (TFA) mediated hydration of ynamides was developed, which is an efficient approach for the synthesis of N-monosubstituted amides. This convenient method is effective with a wide range of substrates under room temperature condition, and the products are obtained in high to excellent yields through an easy work-up process.

Mild and Efficient Cobalt-Catalyzed Cross-Coupling of Aliphatic Amides and Aryl Iodides in Water

A convenient protocol for the C-N cross-coupling of aliphatic amides and iodobenzene is demonstrated using a simple and inexpensive Co(C2O4)·2H2O/N,N′-dimethylethylenediamine (DMEDA) catalytic system in water. Good yields of N-arylated products were isolated (up to 85%) and the protocol has been successfully applied to the synthesis of the anticancer drug, flutamide.

Green chemical multi-component one-pot synthesis of fluorinated 2,3-disubstituted quinazolin-4(3H)-ones under solvent-free conditions and their anti-fungal activity

A rapid one-pot solvent-free procedure has been developed for the synthesis of fluorinated 2,3-disubstituted quinazolin-4(3H)-ones by neat three-component cyclocondensation of anthranilic acid, phenyl acetyl chloride and substituted anilines under microwa

Antiimplantation Agents: Part II - 1,2-Diaryl-1,2,3,4-tetrahydroisoquinolines

1,2-Diaryl-3,4-dihydroisoquinolinium derivatives (5) have been synthesised from N-aryl-N-aroyl-β-phenethylamines (4) and found to exhibit no antiimplantation activity in the rat whereas many of the corresponding tetrahydroisoquinolines (6) are active.Structure-activity relationships have also been studied. 1-(p-Fluorophenyl)-6-methoxy-2-phenyl-1,2,3,4-tetrahydroisoquinoline (6u) and its nor derivative (6v) are very potent, while the ortho (6g) and the meta (6n) fluoro analogues as well as the des-fluoro derivative (6d) are quite active.Extensive biological tests have been carried out on 6g.The enantiomers (+)-6p*HCl and (-)-6q*HCl of 6n have similar activity profiles as that of 6n showing no separation of antiimplantation and estrogenic properties.Diastereomeric 2-(2-methyl-2-phenethyl)-1-phenyl-1,2,3,4-tetrahydroisoquinolines (13a and 13b) show similar properties, while the tetracyclic derivative 19 is inactive. 2-Phenoxyethyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline (26) shows moderate activity, but 1-(β-phenethyl)-2-phenyl-1,2,3,4-tetrahydroisoquinoline 29 is inactive.

ANALIDI AD ATTIVITA ANALGESICA ED ANTIPIRETICA

Several trimethylcyclopentyl and trimethylcyclopentenyl acetanilides, mono- and di-substituted on the aromatic nucleus as well as the corresponding acyl derivatives from aniline it self and corresponding phenylacetanilides, were prepared and tested as analgesics and antipyretics.Several compounds exhibit considerable activity in some cases superior to that of acetanilide.