1939-29-3

Basic information

• Product Name: 2,2,2-TRICHLORO-3'-TRIFLUOROMETHYLACETANILIDE
• Synonyms: 3'-TRIFLUOROMETHYL-2,2,2-TRICHLOROACETANILIDE;2,2,2-TRICHLORO-3'-TRIFLUOROMETHYLACETANILIDE;TIMTEC-BB SBB008118;2,2,2-Trichloro-N-[3-(trifluoromethyl)phenyl]acetamide;2,2,2-TRICHLORO-3''-TRIFLUOROMETHYLACETANILIDE ---WHITE CRYSTALLINE---;2,2,2-trichloro-N-[3-(trifluoromethyl)phenyl]ethanamide;AcetaMide, 2,2,2-trichloro-N-[3-(trifluoroMethyl)phenyl]-
• CAS NO: 1939-29-3
• Molecular Formula: C₉H₅Cl₃F₃NO
• Molecular Weight: 306.5
• Mol File: 1939-29-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,2,2-TRICHLORO-3'-TRIFLUOROMETHYLACETANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-TRICHLORO-3'-TRIFLUOROMETHYLACETANILIDE(1939-29-3)
• EPA Substance Registry System: 2,2,2-TRICHLORO-3'-TRIFLUOROMETHYLACETANILIDE(1939-29-3)

Safety Data

• Hazardous Substances Data: 1939-29-3(Hazardous Substances Data)

Usage

General Description

2,2,2-Trichloro-3'-trifluoromethylacetanilide is a chemical compound that is often used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. It is a member of the acetanilide family, which is known for its diverse range of applications. 2,2,2-TRICHLORO-3'-TRIFLUOROMETHYLACETANILIDE is characterized by the presence of three chlorine atoms and a trifluoromethyl group attached to an acetanilide backbone. Its unique structure and properties make it valuable in the development of various industrial and research products. However, it is important to handle this compound with care, as it may have potential health and environmental risks associated with its use.

Upstream product

• 98-16-8 3-trifluoromethylaniline 
• 76-02-8 trifluoroacetyl chloride 

Relevant articles and documents

Synthesis, biological activities and docking studies of pleuromutilin derivatives with piperazinyl urea linkage

Antibiotics resistance is becoming increasingly common, involving almost all antibiotics on the market. Diseases caused by drug resistant bacteria, such as MRSA, have high mortality and negatively affect public health. The development of new drugs would be an effective means of solving this problem. Modifications based on bioactive natural products could greatly shorten drug development time and improve success rate. Pleuromutilin, a natural product from the basidiomycete bacterial species, is a promising antibiotic candidate. In this study, a series of novel pleuromutilin derivatives possessing piperazinyl urea linkage were efficiently synthesised, and their antibacterial activities and bactericidal properties were evaluated via MIC, MBC and Time-kill kinetics assays. The results showed that all compounds exhibited potent activities against tested strains, especially MRSA strains with MIC values as low as 0.125 μg/mL; 8 times lower than that of marketed antibiotic Tiamulin. Docking studies indicate substituted piperazinyl urea derivatives could provide hydrogen bonds and initiate π-π stacking between molecules and surrounding residues.