1939-29-3

Usage

Uses

Used in Pharmaceutical Industry:
2,2,2-Trichloro-3'-trifluoromethylacetanilide is used as a building block for the synthesis of various pharmaceuticals. Its unique structure and properties make it valuable in the development of new drugs with specific therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical industry, 2,2,2-Trichloro-3'-trifluoromethylacetanilide is used as a key intermediate in the synthesis of various agrochemicals, such as pesticides and herbicides. Its presence in these compounds contributes to their effectiveness in controlling pests and weeds in agricultural settings.
Used in Specialty Chemicals Industry:
2,2,2-Trichloro-3'-trifluoromethylacetanilide is also used in the synthesis of specialty chemicals, which are high-value chemicals with specific applications in various industries. Its unique properties make it a valuable component in the development of these specialty chemicals.

Upstream product

• 98-16-8 3-trifluoromethylaniline 
• 76-02-8 trifluoroacetyl chloride 

Relevant academic research and scientific papers

Synthesis, biological activities and docking studies of pleuromutilin derivatives with piperazinyl urea linkage

Antibiotics resistance is becoming increasingly common, involving almost all antibiotics on the market. Diseases caused by drug resistant bacteria, such as MRSA, have high mortality and negatively affect public health. The development of new drugs would be an effective means of solving this problem. Modifications based on bioactive natural products could greatly shorten drug development time and improve success rate. Pleuromutilin, a natural product from the basidiomycete bacterial species, is a promising antibiotic candidate. In this study, a series of novel pleuromutilin derivatives possessing piperazinyl urea linkage were efficiently synthesised, and their antibacterial activities and bactericidal properties were evaluated via MIC, MBC and Time-kill kinetics assays. The results showed that all compounds exhibited potent activities against tested strains, especially MRSA strains with MIC values as low as 0.125 μg/mL; 8 times lower than that of marketed antibiotic Tiamulin. Docking studies indicate substituted piperazinyl urea derivatives could provide hydrogen bonds and initiate π-π stacking between molecules and surrounding residues.