19395-40-5 Usage
Uses
Used in Pharmaceutical Industry:
Alpha-Phenyl-2-piperidineacetic acid hydrochloride is used as an active metabolite for the treatment of ADHD, tachycardia, and narcolepsy. Its role in the metabolism of methylphenidate contributes to the management of these conditions by enhancing focus, reducing hyperactivity, and improving wakefulness.
Used in Urine Drug Testing:
Alpha-Phenyl-2-piperidineacetic acid hydrochloride is used as a biomarker in urine drug testing to detect the presence of methylphenidate, which is prescribed for ADHD, tachycardia, and narcolepsy. This helps in monitoring patient compliance and ensuring the appropriate use of the medication.
Used in Clinical Toxicology:
alpha-Phenyl-2-piperidineacetic acid hydrochloride is used as a diagnostic tool in clinical toxicology to identify and measure the levels of methylphenidate in the blood. This information is crucial for understanding the potential risks and side effects associated with the use of methylphenidate, as well as for guiding treatment strategies in cases of overdose or adverse reactions.
Used in Forensic Analysis:
Alpha-Phenyl-2-piperidineacetic acid hydrochloride is used as an analytical marker in forensic analysis to determine the presence and concentration of methylphenidate in biological samples. This is important for investigating cases involving the misuse or abuse of ADHD medications and for providing evidence in legal proceedings.
Check Digit Verification of cas no
The CAS Registry Mumber 19395-40-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,3,9 and 5 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 19395-40:
(7*1)+(6*9)+(5*3)+(4*9)+(3*5)+(2*4)+(1*0)=135
135 % 10 = 5
So 19395-40-5 is a valid CAS Registry Number.
19395-40-5Relevant academic research and scientific papers
Synthesis and pharmacology of ethylphenidate enantiomers: The human transesterification metabolite of methylphenidate and ethanol
Patrick, Kennerly S.,Williard, Robin L.,VanWert, Adam L.,Dowd, Justin J.,Oatis Jr., John E.,Middaugh, Lawrence D.
, p. 2876 - 2881 (2007/10/03)
Ethanol elevates methylphenidate (1) plasma concentrations and yields the metabolite ethylphenidate (2). The therapeutic implications are tinder investigation. The IC50 for dopamine reuptake inhibition by (+)-2 was 27 nM compared to 367 nM for cocaine and 1730 nM for (-)-2. Binding selectivity for dopamine versus norepinephrine transporters was greater for (+)-2 than for cocaine. Intraperitoneal (+)-2 was approximately half as active as (+)-1 in stimulating mouse motor activity at 5 mg/kg, but (+)-2 was as active as (+)-1 at 10 mg/kg.
