193957-04-9

Basic information

• Product Name: N-[1-[6-(1,2,4-Thiadiazol-5-yl)pyridazin-3-yl]piperidin-4-yl]-N-[3-(trifluoromethyl)phenyl]amine
• Synonyms: R-123942
• CAS NO: 193957-04-9
• Molecular Formula: C₁₈H₁₇F₃N₆S
• Molecular Weight: 406.43559
• Mol File: 193957-04-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[1-[6-(1,2,4-Thiadiazol-5-yl)pyridazin-3-yl]piperidin-4-yl]-N-[3-(trifluoromethyl)phenyl]amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[1-[6-(1,2,4-Thiadiazol-5-yl)pyridazin-3-yl]piperidin-4-yl]-N-[3-(trifluoromethyl)phenyl]amine(193957-04-9)
• EPA Substance Registry System: N-[1-[6-(1,2,4-Thiadiazol-5-yl)pyridazin-3-yl]piperidin-4-yl]-N-[3-(trifluoromethyl)phenyl]amine(193957-04-9)

Safety Data

• Hazardous Substances Data: 193957-04-9(Hazardous Substances Data)

Upstream product

• 1121-79-5 3-chloro-6-methylpyridazine 
• 1047655-42-4 3-chloro-6-(1,2,4-thiadiazol-5-yl)pyridazine 
• 782446-06-4 4-((3-trifluoromethyl-phenyl)-amino)-piperidine 

Relevant articles and documents

Synthesis and anti-angiogenic activity of 6-(1,2,4-thiadiazol-5-yl)-3-amino pyridazine derivatives

General screening for inhibitors of microvessel growth in vitro in the rat aortic ring assay led to the discovery of a novel series of thiadiazole pyridazine compounds with potential anti-angiogenic activity. Chemical optimization produced orally active compounds with potent in vitro and in vivo anti-angiogenesis and anti-tumor activities.