193958-89-3

Upstream product

• 872-31-1 3-Bromothiophene 
• 1993-03-9 o-fluorophenylboronic acid 

Downstream Products

• 1514862-88-4 2,5-dibromo-3-(2-fluorophenyl)thiophene 
• 1514864-34-6 5-d₁-2-bromo-3-(2-fluorophenyl)thiophene 
• 1514865-89-4 2,4,5-d₃-3-(2-fluorophenyl)thiophene 
• 1514864-35-7 4,5-d₂-2-bromo-3-(2-fluorophenyl)thiophene 
• 1514865-91-8 4,-d₁-3-(2-fluorophenyl)thiophene 
• 1514864-31-3 4-d₁-2-bromo-3-(2-fluorophenyl)thiophene 
• 1514863-74-1 C₂₀H₁₀Br₂F₂S₂ 
• 1514862-86-2 2-bromo-3-(2-fluorophenyl)-5-(4-fluorophenyl)thiophene 
• 1227959-00-3 2-bromo-3-(2-fluorophenyl)thiophene 

Relevant academic research and scientific papers

INFLUENZA VIRUS REPLICATION INHIBITOR AND USE THEREOF

Disclosed are a compound as shown in formula (I) as an influenza virus replication inhibitor and a preparation method therefor, a pharmaceutical composition comprising the compound and the use of the compound and pharmaceutical composition thereof in the treatment of influenza.

Gold-catalyzed oxidative coupling of arylsilanes and arenes: Origin of selectivity and improved precatalyst

The mechanism of gold-catalyzed coupling of arenes with aryltrimethylsilanes has been investigated, employing an improved precatalyst (thtAuBr3) to facilitate kinetic analysis. In combination with linear free-energy relationships, kinetic isotope effects, and stoichiometric experiments, the data support a mechanism involving an Au(I)/Au(III) redox cycle in which sequential electrophilic aromatic substitution of the arylsilane and the arene by Au(III) precedes product-forming reductive elimination and subsequent cycle-closing reoxidation of the metal. Despite the fundamental mechanistic similarities between the two auration events, high selectivity is observed for heterocoupling (C-Si then C-H auration) over homocoupling of either the arylsilane or the arene (C-Si then C-Si, or C-H then C-H auration); this chemoselectivity originates from differences in the product-determining elementary steps of each electrophilic substitution. The turnover-limiting step of the reaction involves associative substitution en route to an arene π-complex. The ramifications of this insight for implementation of the methodology are discussed.