193975-42-7Relevant academic research and scientific papers
Synthesis of eight-membered lactones: Intermolecular [6+2] cyclization of amphoteric molecules with siloxy alkynes
Zhao, Wanxiang,Wang, Zhaobin,Sun, Jianwei
, p. 6209 - 6213 (2012)
That's about the size of it: The title molecules react with siloxy alkynes in the presence of a Bronsted acid to deliver medium-sized lactones through a [6+2] cyclization (see scheme; TIPS=triisopropylsilyl). This process is the first intermolecular synthesis of such lactones and involves a sequence of several selective ring-opening/ring-closing events. Copyright
