194025-95-1Relevant academic research and scientific papers
A model β-sheet interaction and thermodynamic analysis of β-strand mimetics
Robinson, Colin W.,Rye, Carl S.,Chessum, Nicola E. A.,Jones, Keith
supporting information, p. 7402 - 7407 (2015/07/15)
β-Sheet mediated protein-protein interactions are involved in key signalling pathways in diseases such as cancer. We present small molecule β-strand mimetics and investigate their interactions with a model tripeptide. Using 1H NMR, the thermodynamic parameters for their binding are determined. These give insight into this biologically important interaction.
A model β-sheet interaction and thermodynamic analysis of β-strand mimetics
Robinson, Colin W.,Rye, Carl S.,Chessum, Nicola E. A.,Jones, Keith
supporting information, p. 7402 - 7407 (2015/11/27)
β-Sheet mediated protein-protein interactions are involved in key signalling pathways in diseases such as cancer. We present small molecule β-strand mimetics and investigate their interactions with a model tripeptide. Using 1H NMR, the thermodynamic parameters for their binding are determined. These give insight into this biologically important interaction.
Solid-phase synthesis of artificial β-sheets
Holmes, Darren L.,Smith, Eric M.,Nowick, James S.
, p. 7665 - 7669 (2007/10/03)
This paper describes the solid-phase syntheses of artificial β-sheets 1-4, which mimic the structure and hydrogen-bonding patterns of protein β-sheets. In these compounds, molecular templates induce β-sheet structures in attached peptide strands. The temp
