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5-Isoquinolinesulfonyl chloride, 4-chloro-, also known as 4-chloro-5-isothiocyanato-1,2,3,4-tetrahydro-1-isoquinoline, is a chemical compound with the molecular formula C10H8ClNOS. It is a white to off-white crystalline solid that is soluble in organic solvents such as ethanol, acetone, and dichloromethane. 5-Isoquinolinesulfonyl chloride, 4-chloro- is primarily used as a reagent in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It is known for its ability to act as a selective inhibitor of certain enzymes, making it a valuable tool in medicinal chemistry research. Due to its reactivity, it is important to handle 5-Isoquinolinesulfonyl chloride, 4-chloro- with care, as it can be harmful if inhaled, ingested, or absorbed through the skin.

194032-34-3

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194032-34-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 194032-34-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,4,0,3 and 2 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 194032-34:
(8*1)+(7*9)+(6*4)+(5*0)+(4*3)+(3*2)+(2*3)+(1*4)=123
123 % 10 = 3
So 194032-34-3 is a valid CAS Registry Number.

194032-34-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-chloroisoquinoline-5-sulfonyl chloride

1.2 Other means of identification

Product number -
Other names 4-chloro-5-chlorosulfonylisoquinoline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:194032-34-3 SDS

194032-34-3Downstream Products

194032-34-3Relevant academic research and scientific papers

ROCK KINASE INHIBITORS

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, (2020/05/29)

The present invention relates to compounds that inhibit ROCK activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of inhibiting ROCK activity and methods for treating, for example cerebral cavernous malformation syndrome (CCM) and cardiovascular diseases using the compounds and pharmaceutical compositions of the present invention.

ISOQUINOLINESULFONYL DERIVATIVE AS RHO KINASE INHIBITOR

-

, (2017/06/12)

The present invention discloses a class of isoquinolinesulfonyl derivatives as RHO kinase inhibitors, and pharmaceutical compositions thereof, and relates to pharmaceutically acceptable uses thereof. Specifically, the present invention relates to a compound as represented by formula (I), or a pharmaceutically acceptable salt thereof.

Isoquinoline derivatives and drugs

-

, (2008/06/13)

PCT No. PCT/JP97/00240 Sec. 371 Date Jul. 29, 1998 Sec. 102(e) Date Jul. 29, 1998 PCT Filed Jan. 31, 1997 PCT Pub. No. WO97/28130 PCT Pub. Date Aug. 7, 1997The invention relates to a compound of the following general formula [I] or a medicinally acceptable salt thereof, or a solvate thereof, wherein R1 represents alkyl, alkenyl, alkynyl, alkoxy, hydroxy, cyano, or halogen; R2 represents hydrogen, hydroxy, or halogen; R3 represents hydrogen, alkyl, or amidino; Ring A represents a 5 to 11-membered cyclic amino group which may be substituted, which cyclic amino group may be bridged between two carbon atoms in optional positions. The compound of this invention is useful for the prevention or treatment of cerebral tissue impairment due to the vasospasm following cerebral hemorrhage.

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