19404-23-0 Usage
Uses
Used in Pharmaceutical Industry:
3-Methyl-benzo[b]thiophene-5-carbonitrile is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Methyl-benzo[b]thiophene-5-carbonitrile serves as a starting material for the creation of novel agrochemicals, contributing to the advancement of crop protection and management solutions.
Used in Research and Development:
3-Methyl-benzo[b]thiophene-5-carbonitrile is employed as a research chemical, providing a foundation for the preparation of a wide array of organic compounds. Its use in this context facilitates the exploration of new chemical reactions and the discovery of innovative applications in both academia and industry.
Used in Medicinal Chemistry:
3-Methyl-benzo[b]thiophene-5-carbonitrile is leveraged in medicinal chemistry for its potential to contribute to the design and synthesis of new therapeutic agents, capitalizing on its distinctive structural features to address unmet medical needs.
Used in Material Science:
In the realm of material science, 3-Methyl-benzo[b]thiophene-5-carbonitrile is explored for its capacity to enhance or create new materials with unique properties, such as improved stability, reactivity, or selectivity in various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 19404-23-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,4,0 and 4 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 19404-23:
(7*1)+(6*9)+(5*4)+(4*0)+(3*4)+(2*2)+(1*3)=100
100 % 10 = 0
So 19404-23-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H7NS/c1-7-6-12-10-3-2-8(5-11)4-9(7)10/h2-4,6H,1H3
19404-23-0Relevant academic research and scientific papers
Reductive cyanation of organic chlorides using CO2 and NH3 via Triphos–Ni(I) species
Dong, Yanan,Li, Yuehui,Yang, Peiju,Zhao, Shizhen
, (2020/08/19)
Cyano-containing compounds constitute important pharmaceuticals, agrochemicals and organic materials. Traditional cyanation methods often rely on the use of toxic metal cyanides which have serious disposal, storage and transportation issues. Therefore, there is an increasing need to develop general and efficient catalytic methods for cyanide-free production of nitriles. Here we report the reductive cyanation of organic chlorides using CO2/NH3 as the electrophilic CN source. The use of tridentate phosphine ligand Triphos allows for the nickel-catalyzed cyanation of a broad array of aryl and aliphatic chlorides to produce the desired nitrile products in good yields, and with excellent functional group tolerance. Cheap and bench-stable urea was also shown as suitable CN source, suggesting promising application potential. Mechanistic studies imply that Triphos-Ni(I) species are responsible for the reductive C-C coupling approach involving isocyanate intermediates. This method expands the application potential of reductive cyanation in the synthesis of functionalized nitrile compounds under cyanide-free conditions, which is valuable for safe synthesis of (isotope-labeled) drugs.
Triazole containing indole derivatives
-
, (2008/06/13)
A class of substituted imidazole, triazole and tetrazole derivatives are selective agonists of 5-HT 1 -like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and associated disorders, for which a selective agonist of these receptors is indicated.
