19415-40-8

Usage

Uses

Used in Organic Synthesis:
2-(Chloromethyl)-4-fluoro-1-methoxybenzene is used as a key intermediate in organic synthesis for the production of various chemical compounds. Its unique structure, with a chloromethyl group, allows for further functionalization and the creation of a wide range of derivatives.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-(Chloromethyl)-4-fluoro-1-methoxybenzene is used as a building block for the synthesis of drugs and pharmaceuticals. Its presence in the molecular structure can contribute to the development of new therapeutic agents with specific properties, such as improved pharmacokinetics or targeted delivery.
Used in Chemical Reactions:
2-(Chloromethyl)-4-fluoro-1-methoxybenzene is employed as a reactant in various chemical reactions, where its functional groups can participate in substitution, addition, or other types of reactions to yield desired products. Its versatility in chemical transformations makes it a valuable compound in the field of chemistry.
Used in Research and Development:
2-(Chloromethyl)-4-fluoro-1-methoxybenzene is utilized in research and development for the exploration of new chemical pathways and the discovery of novel compounds with potential applications in various industries, including pharmaceuticals, materials science, and agrochemicals.

InChI:InChI=1/C8H8ClFO/c1-11-8-3-2-7(10)4-6(8)5-9/h2-4H,5H2,1H3

Upstream product

• 459-60-9 1-fluoro-4-methoxybenzene 
• 109-87-5 Dimethoxymethane 
• 50-00-0 formaldehyd 
• 426831-32-5 (5-fluoro-2-methoxyphenyl)methanol 

Downstream Products

• 157518-45-1 trans-3-(5-fluoro-2-methoxyphenyl)propenoic acid 
• 157604-02-9 (E)-1-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-(5-fluoro-2-methoxy-phenyl)-propenone 
• 501008-41-9 2-(5-fluoro-2-methoxyphenyl)acetonitrile 
• 888972-77-8 4-[(5-fluoro-2-methoxyphenyl)methyl]-1-piperazinecarboxylic acid, 1,1-dimethylethyl ester 
• 800407-86-7 (S,R)-1-(4-benzyl-morpholin-2-yl)-2-(5-fluoro-2-methoxy-phenyl)-1-phenyl-ethanol 
• 1615714-12-9 1-(5-fluoro-2-methoxybenzyl)-3-iodo-7-methyl-1H-pyrrolo[3,2-b]pyridine 
• 303043-49-4 2-(3-chloro-propoxymethyl)-4-fluoro-1-methoxy-benzene 
• 19415-51-1 5-fluoro-2-methoxybenzaldehyde 

Relevant academic research and scientific papers

PHENOXYACETIC ACID DERIVATIVES USEFUL FOR TREATING RESPIRATORY DISEASES

The invention relates to substituted phenoxyacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.Formula (I)

NOVEL DERIVATIVES OF DICARBOXYLIC ACID HAVING PHARMACEUTICAL PROPERTIES

The invention relates to compounds of formulae (II), (IV), and (VI) as shown below, wherein the several variable groups are as defined in the specification and claims. Processes for making these materials, and methods for using them in the synthesis of compounds for treatment of cardiovascular disorders and fibrotic disorders are also disclosed.

TREATMENT OF LEARNING DISABILITIES AND MOTOR SKILLS DISORDER WITH NOREPINEPHRINE REUPTAKE INHIBITORS

Provided are methods and medicaments for treating a learning disability or a Motor Skills Disorder, comprising administering to a patient in need of such treatment an effective amount of a selective norepinephrine reuptake inhibitor.

TREATMENT OF PERVASIVE DEVELOPMENTAL DISORDERS WITH NOREPINEPHRINE REUPTAKE INHIBITORS

Provided are methods and medicaments for treating a Pervasive Developmental Disorder, comprising administering to a patient in need of such treatment an effective amount of a selective norepinephrine reuptake inhibitor.

MORPHOLINE DERIVATIVES AS NOREPINEPHRINE REUPTAKE INHIBITORS

Compounds of the general formula (I) are inhibitors of the reuptake of norepinephrine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system.

TREATMENT OF HOT FLASHES, IMPULSE CONTROL DISORDERS AND PERSONALITY CHANGE DUE TO A GENERAL MEDICAL CONDITION

Selective norepinephrine reuptake inhibitors are useful for the prevention or treatment of hot flashes, vasomotor symptoms, impulse control disorders or personality change due to a general medical condition.

ARYL AND HETEROARYL MORPHOLINE DERIVATIVES

Compounds of formula (I) are selective inhibitors of the reuptake of norepinephrine, wherein Rx is H; Ry is H or C1-C4 alkyl; each Rz is independently H or C1-C4 alkyl; X represents O; Y represents OH or OR; R is C1-C4 alkyl; and Ar1 and Ar2 are optionall

Stereoselectivity and Generality of the Palladium-Catalysed Cyclopropanation of α,β-Unsaturated Carboxylic Acids Derivatized with Oppolzer's Sultam

A series of α,β-unsaturated carboxylic acids derivatized with camphorsultam 1 a s a chiral auxiliary has been stereoselectively cyclopropanated. the selectivity of the reaction produces cyclopropanated products with the 1R,2R absolute configuration as indicated by the optical rotations as well as by an X-ray structure determineation.The temperature dependence of the reaction was studied with three substrates. the highest stereoselectivity was obtained at temperatures above 25 deg C.Branching at the α- or β-carbons disfavours complete conversion, and electron-withdrawing substituents at these positions seem to prevent the reaction.The auxiliary was removed by using titanium(IV) isopropoxide in benzyl alcohol followed by alkaline hydrolysis of the intermediate ester. the potent 5-HT1A receptor agonist (1R,2S)-2-(2-hydroxyphenyl)-N,N-dipropylcyclopropylamine 13 was synthesized by this method