194159-22-3

Basic information

• Product Name: O-Acetyl N-Benzyloxycarbonyl Valganciclovir
• Synonyms: O-Acetyl N-Benzyloxycarbonyl Valganciclovir;N-[(PhenylMethoxy)carbonyl]-L-valine 3-(Acetyloxy)-2-[(2-aMino-1,6-dihydro-6-oxo-9H-purin-9-yl)Methoxy]propyl Ester
• CAS NO: 194159-22-3
• Molecular Formula: C₂₄H₃₀N₆O₈
• Molecular Weight: 530.5304
• Product Categories: Amino Acids & Derivatives;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals
• Mol File: 194159-22-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.42±0.1 g/cm3(Predicted)
• PKA: 9.31±0.20(Predicted)
• CAS DataBase Reference: O-Acetyl N-Benzyloxycarbonyl Valganciclovir(CAS DataBase Reference)
• NIST Chemistry Reference: O-Acetyl N-Benzyloxycarbonyl Valganciclovir(194159-22-3)
• EPA Substance Registry System: O-Acetyl N-Benzyloxycarbonyl Valganciclovir(194159-22-3)

Safety Data

• Hazardous Substances Data: 194159-22-3(Hazardous Substances Data)

Usage

Uses

Protected Valganciclovir, a pro-drug of ganciclovir.

Upstream product

• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 88110-89-8 9-<(1-acetoxy-2-hydroxymethyl)ethoxymethyl>guanine 

Downstream Products

• 194154-40-0 2-(2-amino-1,6 dihydro-6-oxo-purine-9-yl)-methoxy-3-hydroxy-1-propyl-N-(benzyloxy carbonyl)-L-valinate 

Relevant articles and documents

Preparation of ester of purine derivatives

A process for the preparation of valganciclovir with triacetyl ganciclovir (V) as a starting material, comprising the following steps: selective hydrolysis, reacting with a coupling agent and a solvent, followed by hydrolysis under basic conditions and hydrogenolysis in the presence of a catalyst.