19416-48-9Relevant articles and documents
A tumor microenvironment (TME)-responsive nanoplatform for systemic saporin delivery and effective breast cancer therapy
Shen, Qian,Xu, Lei,Li, Rong,Wu, Guang,Li, Senlin,Saw, Phei Er,Zhou, Yusheng,Xu, Xiaoding
, p. 2563 - 2566 (2021)
Intracellular delivery of therapeutic proteins remains a challenge for the success of protein-mediated disease treatment. We herein develop a robust nanoplatform made with a TME-pH responsive Meo-PEG-b-PPMEMA polymer and a cationic lipid-like compoundG0-C14forin vivodelivery of cytotoxic saporin and breast cancer therapy. This nanoplatform could respond to a TME pH to rapidly release saporin/G0-C14complexes, which could significantly improve the uptake of cytosolic saporin by tumor cells and subsequent endosomal escape, thereby leading to an effective inhibition of tumor growth.
(Meth) acrylic acid ester manufacturing method of N, N-substituted amino alcohol
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Paragraph 0090-0094, (2017/02/23)
The present invention relates to a process for preparing (meth)acrylic esters (F) of N,N-substituted amino alcohols, by transesterifying N,N-substituted amino alcohols (I) in which Y and Z are each independently C1-C20-alkyl, C3-C15-cycloalkyl, aryl, or Y and Z together with the nitrogen atom connecting them form a 5- to 9-membered saturated heterocyclic radical which optionally has oxygen, sulfur, nitrogen or C1-C4-alkyl-substituted nitrogen as a further heteroatom, and X is C2-C20-alkylene which may be interrupted by 1 to 10 nonadjacent oxy groups and/or unsubstituted or methoxy-substituted C1-C4-alkylimino groups, or C3-C15-cycloalkylene, with at least one (meth)acrylic ester (D) in the presence of at least one heterogeneous catalyst (K), wherein the heterogeneous catalyst (K) is used without any further solvent and the content of polymerization inhibitors in the reaction mixture is 450 ppm, and to the use of the (meth)acrylic esters (F) of N,N-substituted amino alcohols.
