19418-11-2Relevant articles and documents
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Sacharkin,Kornewa
, p. 852,854;engl.Ausg.S.828,830 (1958)
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DERIVATIVES OF XANTHINE, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREFOR
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, (2008/06/13)
The present invention is a novel disubstituted derivative of xanthine, pharmaceutical composition and method of use therefor. Activity of the novel xanthine includes particularly cognition activation.
Metabolism of Thiophene-2-carboxylate by a Photosynthetic Bacterium
Tanaka, Hideoki,Maeda, Hidekatsu,Suzuki, Hideo,Kamibayashi, Akira,Tonomura, Kenzo
, p. 1429 - 1438 (2007/10/02)
A photosynthetic bacterium, which can grow photosynthetically on benzoate, was isolated from sewage mud.Various kinds of aromatic compounds including heterocyclic aromatic compounds were photometabolized by the washed cells grown photosynthetically on benzoate with no lag period.Among these, thiophene-2-carboxylate was metabolized most rapidly to its (+)- tetrahydro derivative.The same strain could also grow on succinate under photosynthetic conditions.However, thiophene-2-carboxylate was only photometabolized after a long lag period by the washed cells grown photosynthetically on succinate, and the metabolite was not its (+)-tetrahydro derivative but (+)-3-hydroxytetrahydrothiophene-2-carboxylate.In the presence of chloramphenicol, an inhibitor of protein synthesis, the photometabolism of thiophene-2-carboxylate by the washed cells grown photosynthetically on benzoate was not affected at all, but the photometabolism of the same substrate by the washed cells grown photosynthetically on succinate was completely inhibited.These results indicate that a reduction system of broad substrate specificity for aromatic rings is already present in the benzoate-grown cells but absent in the succinate-grown cells.It seems that such a reduction system for aromatic rings is induced by an aromatic substrate.
