19431-20-0Relevant articles and documents
Stereospecific reduction of keto group in 3β-triphenylmethoxy-5α -cholest-8(14)-en-15-one
Ignatov,Misharin
, p. 167 - 168 (2007/10/03)
The reduction of 3β-triphenylmethoxy-5α-cholest-8(14)-en-15-one with lithium aluminum hydride resulted in a quantitative yield of 3β-triphenylmethoxy-5α-cholest-8(14)-en-15β-ol.
Synthesis of meiosis-activating sterols containing fluorine
Wenckens, Martin,Gronvald, Frederik,Hansen, John Bondo
, p. 503 - 507 (2007/10/03)
It is documented that specific types of sterol play a major role in the resumption of meiosis in oocytes from mice in vitro. 4,4-Dimethyl-5α-cholesta-8,14,24-trien-3β-ol (FF-MAS) isolated from human follicular fluid and 4,4-dimethyl-5α-cholesta-8,24-dien-3β-ol (T-MAS) isolated from bull testicular tissue, have been shown to activate (promote) meiosis in vitro. In order to evaluate the biological activity and stability of such compounds, new demethylsterol derivatives have been synthesised. Using diethylaminosulfur trifluoride (DAST) it was possible to synthesise selected Δ8, Δ14 sterols with mono and difluoro substitution at C3. Acta Chemica Scandinavica 1998.