1944-80-5

Upstream product

• 629-72-1 pentadecyl bromide 
• 603-35-0 triphenylphosphine 

Downstream Products

• 13299-00-8 L-Arabino-1.2.3.4-tetrahydroxy-eicosan 
• 164988-64-1 (E)-(2R,3S,4R)-1,3,4-Tris-benzyloxy-icos-5-en-2-ol 
• 925222-38-4 (R,Z)-1-benzyl-2-(hexadec-1-enyl)aziridine 
• 925222-29-3 (R)-2-{[(Z)-hexadec-1-enyl]-1-[(R)-1-phenylethyl]}aziridine 
• 111394-71-9 (2S)-octadec-3(Z)-ene-1,2-diol 
• 634586-98-4 {(Z)-(S)-1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-heptadec-2-enyl}-carbamic acid benzyl ester 
• 1391485-12-3 (2R,3S,4S)-2-(N,N-dibenzylamino)-4-fluorooctadecane-1,3-diol 
• 1391485-14-5 (R,R,R)-2-(N,N-dibenzylamino)-4-fluorooctadecane-1,3-diol 
• 1391485-15-6 (2S,3R,4R)-2-tetradecyl-4-(N,N-dibenzylamino)tetrahydrofuran-3-ol 
• 1396124-26-7 C₃₄H₅₅NO₅ 
• 634587-01-2 (3S,4S,5R)-1-O-(tert-butyldimethylsilyl)-3-[(benzyloxycarbonyl)amino]-4,5-nonadecanediol 
• 634587-04-5 (3S,4R,5S)-1-O-(tert-butyldimethylsilyl)-3-[(benzyloxycarbonyl)amino]-4,5-nonadecanediol 
• 603-35-0 triphenylphosphine 
• 119269-24-8 3-n-hexadecylthiophene 

Relevant academic research and scientific papers

Dihydroxylation of 2-vinylaziridine: Efficient synthesis of D-ribo-phytosphingosine

An efficient and highly stereoselective synthesis of D-ribo-(2S,3S,4R)- phytosphingosine was accomplished in 62% overall yield starting from commercially available (2S)-hydroxymethylaziridine via osmium-catalyzed asymmetric dihydroxylation as a key step. The Royal Society of Chemistry.

Highly anti-selective dihydroxylation of 1,2-dialkyl substituted (Z)-allylic amines: stereoselective synthesis of a d-ribo-phytosphingosine derivative

Protection of 1,2-dialkyl substituted (Z)-allylic amines with an N,N-diBoc group resulted in an opposite stereoselectivity in the OsO4-catalyzed dihydroxylation reactions to that of N-Boc-(Z)-allylic amines. A higher anti selectivity (>10:1) wa

Protein and peptide-free synthetic vaccines against streptococcus pneumoniae type 3

The present invention provides a protein- and peptide-free conjugate comprising a synthetic carbohydrate and a carrier molecule, wherein the synthetic carbohydrate is a Streptococcus pneumoniae type 3 capsular polysaccharide related carbohydrate and the carrier molecule is a glycosphingolipid. Said conjugate and pharmaceutical composition thereof are useful for immunization against diseases associated with Streptococcus pneumoniae, and more specifically against diseases associated with Streptococcus pneumoniae type 3.

PROTEIN AND PEPTIDE-FREE SYNTHETIC VACCINES AGAINST STREPTOCOCCUS PNEUMONIAE TYPE 3

The present invention provides a protein- and peptide-free conjugate comprising a synthetic carbohydrate and a carrier molecule, wherein the synthetic carbohydrate is a Streptococcus pneumoniae type 3 capsular polysaccharide related carbohydrate and the carrier molecule is a glycosphingolipid. Said conjugate and pharmaceutical composition thereof are useful for immunization against diseases associated with Streptococcus pneumoniae, and more specifically against diseases associated with Streptococcus pneumoniae type 3.

Convenient synthesis of D- and L-xylo-1,2,3,4-alkane tetrols from a D-gluco-configured common building block

D-gluco-Configured building block derived from d-(+)-gluconolactone has served as a common chiral template for the synthesis of enantiopure d- and l-xylo-configured 1,2,3,4-alkane tetrols. This has enabled synthesis of medicinally important guggultetrols and their enantiomers from a common starting point. Wittig and Grignard reactions are the key steps used for the incorporation of lipophilic chain.

Structure-based discovery of glycolipids for CD1d-mediated NKT cell activation: Tuning the adjuvant versus immunosuppression activity

Introduction of an aromatic group into the fatty acyl chain of α-GalCer modulates the activity and selectivity of IFN-γ/IL-4 secretion through CD1d-mediated activation of NKT cells. Compound 14-16 are more potent than α-Galcer and biased for IFN-γ than fo

Use of synthetic glycolipids as universal adjuvants for vaccines against cancer and infectious diseases

The present invention relates to methods and compositions for augmenting an immunogenicity of an antigen in a mammal, comprising administering said antigen together with an adjuvant composition that includes a synthetic glycolipid compound of Formula I, a

SYNTHETIC C-GLYCOLIPID AND ITS USE FOR TREATING CANCER INFECTIOUS DISEASES AND AUTOIMMUNE DISEASES

The invention is directed to compounds of formula (I) wherein X is O, OR NH; R' is a hydrocarbon chain; R and are hydrogen, OH or a monosaccharide; R is hydrogen or a monosaccharide; Q' is optionally present and may be a C1-10 hydrocarbon; X' i

Phytosphingosines - A facile synthesis and spectroscopic protocol for configurational assignment

A facile synthesis of four of the eight configurational isomers of phytosphingosine has been performed by employing Wittig and Julia olefination followed by Sharpless dihydroxylation. The set of these four stereoisomers served as model compounds for developing general chemical/CD/NMR protocols for assigning relative and absolute configurations of all phytosphingosine isomers. The procedure is based on a two-step derivatization to 2-N- naphthimide-1,3,4-0-trinaphthoate derivatives which gives rise to unique exciton coupled circular dichroic and 'H-NMR spectra in selected solvents. The spectra can be used as reference data for assignment of relative as well as absolute configurations of phytosphingosine isomers and congeners at the low-nanomole level.

Chemoenzymatic synthesis of (+)-docosa-4,15-dien-l-yn-3-ol, a component of the marine sponge Cribrochalina vasculum, and confirmation of the structure, and absolute configuration of the acetylenic alcohol, by lipase-catalysed biotransformations

The (4E,15Z)-, and (4￡,15￡)-isomers of (+)-docosa-4,15-dien-l-yn-3-ol 1, isolated from the marine sponge Cribroclialina vasculwn, were synthesized in highly enantiomerically pure form by lipase-mediated biotransformation with Novozym 435, and the structur