19446-29-8Relevant academic research and scientific papers
Synthesis and biological evaluation of N-(4-t-amino-2-butynyloxy) and N-(4-t-amino-2-butynyl) phthalimides
Eldeen,Shubber,Musa,et al.
, p. 85 - 88 (2007/10/02)
A series of N-(4-t-amino-2-butynyloxy) and N-(4-t-amino-2-butynyl) phthalimides have been prepared through the Mannich reaction from N-(propargyloxy) phthalimide or N-propargylphthalimide with formaldehyde and various cyclic amines. These compounds have been investigated for blockade of oxotremorine in intact mice, and for their antagonistic activity towards acetylcholine on isolated guinea pig ileal preparations. None of the oxyphthalimido derivatives show oxotremorine antagonistic activity, but all have an acetylcholine antagonistic activity. The phthalimido compounds, on the other hand, have both oxotremorine and acetylcholine antagonistic activity.
