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4H-Pyrido[1,2-a]pyrimidin-4-one, 2-(3-methylphenyl)- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

194466-62-1

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194466-62-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 194466-62-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,4,4,6 and 6 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 194466-62:
(8*1)+(7*9)+(6*4)+(5*4)+(4*6)+(3*6)+(2*6)+(1*2)=171
171 % 10 = 1
So 194466-62-1 is a valid CAS Registry Number.

194466-62-1Downstream Products

194466-62-1Relevant academic research and scientific papers

Pd-catalyzed carbonylative cycloamidation of ketoimines for the synthesis of pyrido[1,2-a]pyrimidin-4-ones

Xie, Ying,Chen, Tengfei,Fu, Shaomin,Jiang, Huanfeng,Zeng, Wei

, p. 9377 - 9380 (2015)

The Pd(ii)-catalyzed pyridine-directed carbonylative cycloamidation of ketoimines has provided an efficient protocol for assembly of pyrido[1,2-a]pyrimidin-4-ones. This journal is

Silver-catalyzed highly efficient synthesis of pyrido[1,2-a]pyrimidin-4-ones from 2-aminopyridines and alkynoates

Chen, Zhengwang,Wen, Yuelu,Ding, Hao,Luo, Guotian,Ye, Min,Liu, Liangxian,Xue, Jun

supporting information, p. 13 - 16 (2016/12/23)

Pyrimidinone is one of the important nitrogen containing heterocycles due to their wide range of bioactivities. An efficient silver-catalyzed intermolecular cyclization of 2-aminopyridines with various alkynoates has been developed. 2-Substituted 4H-pyrido[1,2-a]pyrimidin-4-ones containing a wide range of functional groups are synthesized in the standard conditions. This transformation is conducted under convenient conditions and affords products in good yields.

Method for treating tumors using 2-aryl-naphthyridin-4-ones

-

, (2008/06/13)

The present invention provides compounds of Formula I: STR1 wherein A and R1 -R8 are defined herein. The compounds of Formula I inhibit the polymerization of tubulin and possess antimitotic activity. The compounds of Formula I may be useful for the treatment of psoriasis, gout, papiloma, warts, and a variety of tumors.

Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization

Chen, Ke,Kuo, Sheng-Chu,Hsieh, Ming-Chieh,Mauger, Anthony,Lin, Chii M.,Hamel, Ernest,Lee, Kuo-Hsiung

, p. 3049 - 3056 (2007/10/03)

As part of our continuing search for potential anticancer drug candidates in the 2-aryl-1,8-naphthyridin-4(1H)-one series, we have synthesized two series of 3'-substituted 2-phenyl-1,8-naphthyridin-4(1H)- ones and 2-naphthyl-1,8-naphthyridin-4(1H)-ones. A

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