194469-86-8Relevant academic research and scientific papers
Inhibitory activities against topoisomerase I & II by polyhydroxybenzoyl amide derivatives and their structure-activity relationship
Abdel-Aziz, Mohamed,Matsuda, Kazuya,Otsuka, Masami,Uyeda, Masaru,Okawara, Tadashi,Suzuki, Keitarou
, p. 1669 - 1672 (2007/10/03)
o-, m-, p-Phenylenediamines having 2,3,4-trihydroxy, 3,4 dihydroxy, and 4-hydroxybenzoyl moieties were prepared and their inhibitory activities were measured against topoisomerase I and II. More hydroxy groups on two aromatic rings increased the activities. Bis(trihydroxybenzoyl)-o-phenylenediamide showed IC50=0.90 and 0.09 μM against topoisomerase I and II, respectively. Compounds with hydroxy groups protected by acetyl moiety still had the activities. Less hydroxy groups decreased their activities. Benzothiazole derivatives also indicated the activities.
Supramolecular self-recognition and self-assembly in gallium(III) catecholamide triple helices
Caulder,Raymond
, p. 1440 - 1442 (2007/10/03)
Remarkable ability for self-recognition is displayed when a mixture of three different bis(catecholamide) ligands is allowed to react at room temperature with [Ga(acac)3] and KOH in methanol. These rigid, rodlike ligands differing only in the d
