194470-90-1Relevant academic research and scientific papers
Absolute stereostructure of callystatin A, a potent cytotoxic polyketide from the marine sponge, Callyspongia truncata
Murakami, Nobutoshi,Wang, Weiqi,Aoki, Masashi,Tsutsui, Yasuhiro,Higuchi, Kouichi,Aoki, Shunji,Kobayashi, Motomasa
, p. 5533 - 5536 (1997)
The unidentified configurations at C5 and C10 incallystatin A (1), a potent cytotoxic polyketide from the marine sponge Callyspongia truncata, were determined to be R,R by comparing the circular dichroism spectrum of 1 with those of two model compounds 2 and 3. Compounds 2 and 3 were synthesized by using E-selective Wittig olefination at the C6-C7 position as a key reaction.
