194486-77-6

Usage

InChI:InChI=1/C4H4N6O5/c5-1-3(9(12)13)7-4(10(14)15)2(6)8(1)11/h5-6H2

Upstream product

• 41536-72-5 2,6-diamino-1λ⁵-pyrazin-1-one 
• 52173-59-8 2,6-diamino-3,5-dinitro-pyrazine 

Relevant academic research and scientific papers

An improved synthesis of 2,6-diamino-3,5-dinitropyrazine-1-oxide

An improved synthesis of 2,6-diamino-3,5-dinitropyrazine-1-oxide (LLM-105) is described, using N-nitroso-bis- (cyanomethyl)amine as the starting material in four steps including cyclisation, acidification; nitration and N-oxidation with a total yield of 54%. The factors influencing the reaction steps are discussed.

A 2, 6 - diamino - 3, 5 - dinitro pyrazine - 1 - oxide synthesis method (by machine translation)

The invention relates to a 2, 6 - diamino - 3, 5 - dinitro pyrazine - 1 - oxide synthesis method, the method is the use of acetic anhydride will be 2, 6 - diamino - 3, 5 - dinitro pyrazine acylation is soluble acetylation product, then hydrogen peroxide o

Synthetic method of 2,6-diamino-3,5-dinitro pyrazine-1-oxide

The invention discloses a synthetic method of 2,6-diamino-3,5-dinitro pyrazine-1-oxide. The synthetic method comprises the following steps: mixing 2,6-diamino-3,5-dinitro pyrazine-1-oxide with sulfuric acid to be taken as a starting material; mixing nitric acid with the mass fraction more than 65% with sulfuric acid with the mass fraction more than 92% or mixing nitrate with the sulfuric acid with the mass fraction more than 92% to be taken as a nitration reagent; pumping the starting material and the nitration reagent into two inlets of a micro-channel reactor in parallel by virtue of a metering pump, mixing the starting material and the nitration reagent in the micro-channel reactor, and carrying out reaction; then outputting to a collector from the micro-channel reactor, and continuously reacting; and then separating and purifying products, so that the 2,6-diamino-3,5-dinitro pyrazine-1-oxide is obtained. The synthetic method disclosed by the invention has the advantages that a micro-channel reaction technology is fully utilized, the nitration reaction efficiency is improved, and full nitration of reaction materials is realized by adopting a collector heat preservation way.

2,6-diamino-3,5-dinitropyrazine-1-oxide synthetic method

The invention discloses a 2,6-diamino-3,5-dinitropyrazine-1-oxide synthetic method. The synthetic method comprises the following steps: adding 2,6-diamino-3,5-dinitropyrazine into trifluoroacetic acid, stirring, dropwise adding hydrogen peroxide into 2,6-diamino-3,5-dinitropyrazine according to the molar ratio of 2,6-diamino-3,5-dinitropyrazine to hydrogen peroxide being 1:10, loading an ultrasonic external field for assisting, controlling the reaction temperature to be 25-35 DEG C, reacting for 4-6 h, and carrying out filtering, washing and drying, so as to obtain the 2,6-diamino-3,5-dinitropyrazine-1-oxide. According to the 2,6-diamino-3,5-dinitropyrazine-1-oxide synthetic method in which the ultrasonic external field is loaded for assisting, the operation is simple and convenient, the reaction condition is mild, the reaction time is greatly shortened, and the industrialized enlargement is facilitated.

Synthetic method for 2,6-diamino-3,5-dinitro-1-oxypyrazine

The invention relates to a synthetic method for a compound, especially to a synthetic method for 2,6-diamino-3,5-dinitro-1-oxypyrazine. The method comprises the following steps: subjecting sodium methoxide and dibromopyrazine to methylation; then carrying

SYNTHESIS OF PYRAZINES INCLUDING 2,6-DIAMINOPYRAZINE-1-OXIDE (DAPO) AND 2,6-DIAMINO-3,5-DINITROPYRAZINE-1-OXIDE (LLM-105)

A method for synthesizing a pyrazine-containing material according to one embodiment includes contacting an iminodiacetonitrile derivative with a base and a reagent selected from a group consisting of hydroxylamine, a hydroxylamine salt, an aliphatic primary amine, a secondary amine, an aryl-substituted alkylamine a heteroaryl-substituted alkyl amine, an alcohol, an alkanolamine and an aryl alcoholamine. Additional methods and several reaction products are presented.

New synthesis of 2,6-diamino-3,5-dinitropyrazine-1-oxide from 2,6-diaminopyrazine-1-oxide

A method for the synthesis of 2,6-Diamino-3,5-dinitropyrazine-1-oxide including nitration of 2,6-diaminopyrazine-1-oxide. The step of nitration may use nitrating agents 20% Oleum/100% HNO3, 100% HNO3 and conc. H2504/100% HNO3 or nitronium tetrfluoraoborate. The synthesis of 2,6-diaminopyrazine-1-oxide may involve both the oxidation of 2,6-diaminopyrazine, the amination of a precursor 2,6-disubstitutedpyrazine-1-oxide or direct formation of the 2,6-diaminopyrazine-l-oxide from the precursor, 2-amino-6-hydroxamino-pyrazine-1-oxide.