194490-17-0

Basic information

• Product Name: 6-CHLORO-3-CYANOINDOLE
• Synonyms: 6-CHLORO-3-CYANOINDOLE;6-CHLORO-1H-INDOLE-3-CARBONITRILE;1H-Indole-3-carbonitrile,6-chloro-
• CAS NO: 194490-17-0
• Molecular Formula: C9H5ClN2
• Molecular Weight: 176.6
• Product Categories: pharmacetical
• Mol File: 194490-17-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 383.8 °C at 760 mmHg
• Flash Point: 185.9 °C
• Appearance: /
• Density: 1.41 g/cm³
• Vapor Pressure: 4.28E-06mmHg at 25°C
• Refractive Index: 1.686
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-CHLORO-3-CYANOINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-3-CYANOINDOLE(194490-17-0)
• EPA Substance Registry System: 6-CHLORO-3-CYANOINDOLE(194490-17-0)

Safety Data

• Hazardous Substances Data: 194490-17-0(Hazardous Substances Data)

Usage

General Description

6-Chloro-3-cyanoindole is a chemical compound with the molecular formula C9H6ClN2. It is a chlorinated derivative of 3-cyanoindole and is commonly used in organic synthesis and pharmaceutical research. 6-CHLORO-3-CYANOINDOLE is often utilized as an intermediate in the production of various pharmaceuticals and agrochemicals. It is known for its versatile reactivity and ability to undergo a variety of chemical reactions, making it a valuable building block in the synthesis of complex organic molecules. Additionally, 6-Chloro-3-cyanoindole has been studied for its potential biological activities and therapeutic applications, further enhancing its significance in the field of chemical and pharmaceutical research.

InChI:InChI=1/C9H5ClN2/c10-7-1-2-8-6(4-11)5-12-9(8)3-7/h1-3,5,12H

Upstream product

• 17422-33-2 6-chloroindole 
• 110-18-9 N,N,N,N,-tetramethylethylenediamine 
• 1144460-70-7 6-chloro-1H-indole-3-carbaldehyde oxime 
• 703-82-2 6-chloro-1H-indole-3-carbaldehyde 

Downstream Products

• 766557-02-2 6-chloro-1H-indole-3-carboxylic acid 

Relevant articles and documents

Copper-mediated C3-cyanation of indoles by the combination of amine and ammonium

A copper-promoted C3-cyanation of both the free N-H and N-protected indoles by N,N,N′,N′-tetramethyl-ethane-1,2-diamine (TMEDA) and ammonium is achieved. The iminium ion acts as the intermediate in this transformation, which is sequentially electrophilically attacked by indole and H2O followed by hydrolyzation to form the aldehyde. Then the reaction between the aldehyde and ammonium afforded nitriles. The reaction employs O2 as a clean oxidant with good efficiency and functional group tolerance. Thus, it represents a facile and safe procedure leading to 3-cyano indoles. The Royal Society of Chemistry 2014.

NITROGENATED HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to novel compounds having a xanthine oxidase inhibitory effect and an uricosuric effect and pharmaceutical compositions comprising the same as an active ingredient. That is, the present invention relates nitrogen-containing heterocyclic compounds represented by the following general formula (I): wherein Y1 represents N or C(R4) ; Y2 represents N or C(R5) ; R4 and R5 independently represent an alkyl group, a hydrogen atom etc. ; one of R1 and R2 represents an optionally substituted aryl group, an alkoxygroup or an optionally substituted heterocyclic group; the other of R1 and R2 represents a haloalkyl group, a cyanogroup, ahalogenatometc.; and R3 represents a 5-tetrazolyl group or a carboxy group, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising the same as an active ingredient.