1945-53-5

Usage

Uses

Used in Pharmaceutical Industry:
PALUSTRICACID is used as an active pharmaceutical ingredient for its antibacterial properties, helping to combat various bacterial infections and contributing to the development of new antibiotics.
Used in Cardiovascular Applications:
PALUSTRICACID is utilized as a cardiovascular agent due to its beneficial effects on the heart and blood vessels, potentially aiding in the treatment and prevention of cardiovascular diseases.
Used in Antioxidant Formulations:
PALUSTRICACID is employed as an antioxidant in the development of products designed to counteract oxidative stress and protect cells from damage, which can be applied in the health and wellness industry.
Used in Cosmetics and Personal Care:
PALUSTRICACID is used as an ingredient in cosmetics and personal care products for its antioxidant and antibacterial properties, enhancing the shelf life and efficacy of these products.
Used in Wood Preservation:
PALUSTRICACID, being a component of pine oleoresin, is used in the wood preservation industry to protect timber from decay, fungi, and insects, thus prolonging its lifespan and maintaining its structural integrity.

InChI:InChI=1/C20H30O2/c1-13(2)14-6-8-16-15(12-14)7-9-17-19(16,3)10-5-11-20(17,4)18(21)22/h12-13,17H,5-11H2,1-4H3,(H,21,22)/t17-,19-,20-/m1/s1

Upstream product

• 79-54-9 levopimaric acid 
• 471-77-2 neoabietic acid 

Downstream Products

• 5309-35-3 abieta-8(14)-en-18-oic acid 9α,13α-endoperoxide 
• 3310-94-9 methyl palustradien-18-oate 

Relevant academic research and scientific papers

Inhibition of platelet aggregation by diterpene acids from Pinus massoniana resin

The acidic fraction of the resin of Pinus massoniana Lamb. from China was converted to the p-nitrophenyl esters, and the esters separated by chromatography. The separated p-nitrophenyl esters were individually hydrolysed by potassium hydroxide in acetone-water at room temperature to 8 diterpene acids of the pimarane and abietane groups: pimaric acid (8(14),15-pimaradien-18-oic acid) (1), levopimaric acid (8(14),12-abietadien-18-oic acid (2), palustric acid (8,13-abietadien-18-oic acid) (3), neoabietic acid (8(14),13(15)-abietadien-18-oic acid) (4), abietic acid (7,13-abietadien-18-oic acid) (5), dehydroabietic acid (8,11,13-abietatrien-18-oic acid) (6), 7-oxodehydroabietic acid (7-oxo-8,11,13-abietatrien-18-oic acid) (7) and 7α-hydroxydehydroabietic acid (7α-hydroxy-8,11,13-abietatrien-18-oic acid) (8). The structure (and stereochemistry) of the diterpene acids were substantiated by nulear magnetic resonance spectroscopy (proton and carbon-13, one and two dimensional), by mass spectrometry (electron impact and methane chemical ionization) and by rotation measurements. The 8 diterpene acids were tested for their ability to inhibit the aggregation of washed rabbit platelets induced by platelet activating factor (PAF), adenosine diphosphate (ADP) and by calcium ionophore A23187. With platelet aggregation induced by the latter two agonists, activities comparable with or higher than linolenic acid were given by the first 4 acids. With aggregation induced by PAF, the first 3 acids show activity, but at a level significantly lower than that of linolenic acid. Levopimaric acid has the highest activity among the diterpene acids tested. It is proposed that this activity is related to the folded shape of the molecule.