194535-52-9

Upstream product

• 930-68-7 cyclohexenone 
• 76899-07-5 (3R,4R)-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-acetoxyazetidin-2-one 
• 194535-46-1 (3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-{(1R,4R)-4-[(E)-3-(1,3-dimethyl-2-oxo-2λ⁵-[1,3,2]diazaphospholidin-2-yl)-allyl]-2-oxo-cyclohexyl}-azetidin-2-one 
• 194535-47-2 ((1R,4R)-4-{(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-3-oxo-cyclohexyl)-acetaldehyde 
• 194535-48-3 (3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-[(1R,4R)-4-(2-hydroxy-ethyl)-2-oxo-cyclohexyl]-azetidin-2-one 
• 194535-43-8 1-{(2S,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-2-oxo-cyclohex-3-enecarboxylic acid allyl ester 
• 194535-45-0 (3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-((R)-2-oxo-cyclohex-3-enyl)-azetidin-2-one 
• 194535-50-7 (3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-{(1R,4R)-4-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-cyclohexyl}-azetidin-2-one 
• 194535-44-9 1-{(2S,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-2-oxo-cyclohex-3-enecarboxylic acid allyl ester 
• 194535-42-7 allyl 2-oxocyclohex-3-ene-1-carboxylate 

Downstream Products

• 194535-54-1 ((2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-{(1R,4R)-4-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-cyclohexyl}-4-oxo-azetidin-1-yl)-oxo-acetic acid benzyl ester 
• 194535-58-5 (1S,6S,8aS,8bR)-1-((R)-1-Hydroxy-ethyl)-6-(2-hydroxy-ethyl)-2-oxo-1,2,5,6,7,8,8a,8b-octahydro-azeto[2,1-a]isoindole-4-carboxylic acid benzyl ester 
• 194535-56-3 (1S,6S,8aS,8bR)-1-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-1,2,5,6,7,8,8a,8b-octahydro-azeto[2,1-a]isoindole-4-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Tricyclic β-lactams: Total synthesis and antibacterial activity of 5α-methoxyethyl and 5α-hydroxyethyl trinems

The total synthesis of the tricyclic β-lactams, 5α-hydroxyethyl and 5α-methoxyethyl trinems is described and preliminary biological evaluation is reported.