19458-46-9

Usage

Chemical classification

20,26-dihydroxyecdysone is an ecdysteroid, a type of steroid hormone found in insects and various plants.

Sources

The compound has been identified in several plant species, including some traditional Chinese medicinal herbs.

Pharmacological activities

20,26-dihydroxyecdysone has shown potential anti-inflammatory, anti-tumor, and anti-diabetic properties.

Effects on muscle growth

The compound has demonstrated positive effects on muscle growth and metabolism.

Relevance to sports nutrition

Due to its effects on muscle growth and metabolism, 20,26-dihydroxyecdysone is of interest for research in sports nutrition and performance enhancement.

Therapeutic potential

The unique biological activities and potential therapeutic applications of 20,26-dihydroxyecdysone make it a promising candidate for further scientific investigation and development of new pharmaceutical agents.

InChI:InChI=1/C27H44O8/c1-23(33,14-28)8-7-22(32)26(4,34)21-6-10-27(35)16-11-18(29)17-12-19(30)20(31)13-24(17,2)15(16)5-9-25(21,27)3/h11,15,17,19-22,28,30-35H,5-10,12-14H2,1-4H3/t15-,17-,19+,20-,21-,22+,23?,24+,25+,26+,27?/m0/s1

Upstream product

• 84507-66-4 20-hydroxyecdysone 2,3:20,22-diacetonide 
• 3604-87-3 ecdysone 
• 13408-48-5 ponasterone A 
• 52717-49-4 26-hydroxyecdysone 

Related news

Naturally occurring 20,26-dihydroxyecdysone (cas 19458-46-9) exists as two C-25 epimers which exhibit different degrees of moulting hormone activity08/17/2019

20,26-Dihydroxyecdysone (20,26-ECD) isolated from Vitex canescens, V. glabrata and V. pinnata has been shown to exist as two C-25 epimers. Synthesis and separation of the two epimers were accomplished and they exhibited different degree of moulting hormone activity in the Musca assay.detailed

Relevant academic research and scientific papers

Naturally occurring 20, 26-dihydroxyecdysone exists as two C-25 epimers which exhibit different degrees of moulting hormone activity

20,26-Dihydroxyecdysone (20,26-ECD) isolated from Vitex canescens, V. glabrata and V. pinnata has been shown to exist as two C-25 epimers. Synthesis and separation of the two epimers were accomplished and they exhibited different degree of moulting hormone activity in the Musca assay.

ECDYSTEROID METABOLISM IN A CRAB: CARCINUS MAENAS L.

Ponasterone A (25-deoxy-20-hydroxyecdysone) and 20-hydroxyecdysone were the major ecdysteroids detected in crab hemolymph, although some ecdysone was also present.The metabolism of ponasterone A was examined in intermolt and premolt crabs either by injecting the radiolabeled hormone or by incubating tissues in its presence.Metabolites were extracted from the surrounding seawater and from tissues and separated by high-performance liquid chromatography.Ponasterone A metabolism proceeds through (1) C-25 and C-26 hydroxylation, followed by formation of inactivation products via oxidation of the terminal alcoholic group to a carboxylic residue, (2) conjugation, (3) binding to very polar compounds and (4) side-chain scission.The conversion of ponasterone A into 20-hydroxyecdysone, inokosterone (25-deoxy-20,26-dihydroxyecdysone), 20,26-dihydroxyecdysone and ecdysonoic acids, as well as the formation of conjugates and of very polar compounds, occurs in various tissues.These metabolites were excreted by both intermolt and premolt crabs.