194597-89-2Relevant academic research and scientific papers
Enantioselective Radical Construction of 5-Membered Cyclic Sulfonamides by Metalloradical C-H Amination
Hu, Yang,Lang, Kai,Li, Chaoqun,Gill, Joseph B.,Kim, Isaac,Lu, Hongjian,Fields, Kimberly B.,Marshall, McKenzie,Cheng, Qigan,Cui, Xin,Wojtas, Lukasz,Zhang, X. Peter
supporting information, p. 18160 - 18169 (2019/11/19)
Both arylsulfonyl and alkylsulfonyl azides can be effectively activated by the cobalt(II) complexes of D2-symmetric chiral amidoporphyrins for enantioselective radical 1,5-C-H amination to stereoselectively construct 5-membered cyclic sulfonami
Synthesis of α-fluorosulfonamides by electrophilic fluorination
Hill, Bryan,Liu, Yong,Taylor, Scott D.
, p. 4285 - 4288 (2007/10/03)
(Chemical Equation Presented) α-Fluorosulfonamides were prepared by electrophilic fluorination of tertiary sulfonamides using N- fluorobenzenesulfonimide as fluorinating agent and utilizing the dimethoxybenzyl group (DMB) as a new sulfonamide protecting g
Novel inhibitors of HIV protease: Design, synthesis and biological evaluation of picomolar inhibitors containing cyclic P1/P2 scaffolds
Spaltenstein, Andrew,Almond, Merrick R.,Bock, William J.,Cleary, Darryl G.,Furfine, Eric S.,Hazen, Richard J.,Kazmierski, Wieslaw M.,Salituro, Francesco G.,Tung, Roger D.,Wright, Lois L.
, p. 1159 - 1162 (2007/10/03)
A novel series of HIV protease inhibitors containing cyclic P1/P2 scaffolds has been synthesized and evaluated for biological activity. The trans 3,5-dibenzyl-2-oxo pyrrolidinone ring system resulted in a 50 pM enzyme inhibitor against HIV protease in vitro when combined with an indanolamine derived P'-backbone. This compound also shows comparable activity to currently marketed drugs in the MT-4 cell-based antiviral assay. (C) 2000 Elsevier Science Ltd. All rights reserved.
