194608-39-4Relevant academic research and scientific papers
New CNS agent precursors. A simple and efficient route for synthesis of 6-aminomethyl-4,5,6,7- tetrahydrobenzofuran-4-ones as conformationally constrained butyrophenone analogues
Casariego, Isabel,Masaguer, Christian F.,Ravina, Enrique
, p. 5555 - 5558 (1997)
Starting from 3,4,5-trimethoxybenzoic acid, we described a practical and efficient five-step synthesis of 6-aminomethyl-4,5,6,7-tetrahydrobenzofuran-4-ones as new CNS agent precursors in an overall yield of 20%.
Conformationally constrained butyrophenones with affinity for dopamine (D1, D2, D4) and serotonin (5-HT(2A), 5-HT(2B), 5-HT(2C)) receptors: Synthesis of aminomethylbenzo[b]furanones and their evaluation as antipsychotics
Ravina,Casariego,Masaguer,Fontenla,Montenegro,Rivas,Loza,Enguix,Villazon,Cadavid,Demontis
, p. 4678 - 4693 (2000)
A series of novel conformationally restricted butyrophenones (6-aminomethyl-4,5,6,7-tetrahydrobenzo[b]furan-4-ones bearing 4-(6-fluorobenzisoxazolyl)piperidine, 4-(p-fluorobenzoyl)piperidine, 4-(o-methoxyphenyl)piperazine, 4-(2-pyridyl)piperazine, 4-(2-py
