194666-01-8

Upstream product

• 61024-94-0 2-bromo-4-tert-butyl-1-methylbenzene 

Downstream Products

• 130840-94-7 4,4'-di-tert-butyl-2,2'-bis(chloromethyl)diphenylethane 
• 194665-97-9 {5-tert-Butyl-2-[2-(4-tert-butyl-2-hydroxymethyl-phenyl)-ethyl]-phenyl}-methanol 
• 159585-56-5 4,4'-di-tert-butyl-2,2'-dimethyldiphenylethane 

Relevant academic research and scientific papers

Selective Preparation of Polycyclic Aromatic Hydrocarbons. Part 7. A Preparative Route to 10,11-Dihydro-5H-dibenzo-cycloheptenes Using Friedel-Crafts Intramolecular Cyclobenzylation

Cyclobenzylation of 2-hydroxymethyldiphenylethanes 4 and 2,2'-bis(hydroxymethyl)diphenylethanes 13 in the presence of a solid perfluorinated sulfonic acid resin, Nafion-H, as a catalyst results in novel polycyclic aromatic hydrocarbons, dibenzocyclopentenes.Dibenzocyclopentenes were also prepared from diphenylethanes by a benzylation reaction, which incorporates chloromethylation of a hydrocarbon followed by Friedel-Crafts intramolecular cyclization reaction.The present method involving the action of ClCH2OMe and TiCl4 on a variety of diphenylethanes (constructed such that electrophilic substitution occurs ortho to the diphenylethane linkage) offers a convenient, mild one-pot synthesis of substituted dibenzocycloheptenes.The mechanism of these reactions is also discussed.