19470-74-7

Upstream product

• 59-48-3 2-oxoindole 
• 552-89-6 2-nitro-benzaldehyde 
• 3342-78-7 2-(2-aminophenyl)acetic acid 

Downstream Products

• 17990-70-4 3-((E)-2-amino-benzylidene)-indolin-2-one 
• 1416007-65-2 (E)-tert-butyl 3-(2-nitrobenzylidene)-2-oxoindoline-1-carboxylate 
• 1416008-77-9 tert-butyl 4'-(2-nitrophenyl)-2-oxo-2',5'-diphenyl-2',4'-dihydrospiro[indoline-3,3'-pyrazole]-1-carboxylate 

Relevant academic research and scientific papers

Design, synthesis, and biological evaluation of oxindole derivatives as antidepressive agents

The 3-substituted oxindole derivatives were designed, synthesized, and evaluated for antidepressant activity by employing forced swimming test, tail suspension test, and MAO-A inhibition assay. Results of biological studies revealed that the majority of c

Asymmetric catalytic 1,3-dipolar cycloaddition reaction of nitrile imines for the synthesis of chiral spiro-pyrazoline-oxindoles

A new 1,3-dipolar cycloaddition of nitrile imines with 3-alkenyl-oxindoles was catalyzed by a new chiral Mg(ClO4)2 complex of an N,N'-dioxide ligand. The reaction is so far the sole catalytic synthesis of spiro-pyrazoline-oxindole derivatives. A wide variety of substrates were explored to obtain good yields (up to 98%) and excellent enantioselectivities (up to 99%). This cycloaddition expands the scope of propargyl anion type 1,3-dipole in the construction of 2-pyrazoline subunit.