194719-99-8

Upstream product

• 194720-00-8 (R)-5-Benzyloxy-2-diazo-4-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyloxy)-pentanoic acid methyl ester 
• 194720-01-9 (R)-1-Benzyloxy-5-(dimethyl-hydrazono)-5-phenyl-pentan-2-ol 
• 14618-80-5 (R)-benzyl glycidol 
• 24163-93-7 farnesyl bromide 
• 194720-12-2 (2R,3R,5R)-5-Benzyloxymethyl-2-((1E,5E)-2,6,10-trimethyl-undeca-1,5,9-trienyl)-tetrahydro-furan-3-carboxylic acid methyl ester 

Downstream Products

• 194720-03-1 [(2R,3R,5R)-5-Benzyloxymethyl-2-((1E,5E)-2,6,10-trimethyl-undeca-1,5,9-trienyl)-tetrahydro-furan-3-yl]-methanol 
• 194720-08-6 Toluene-4-sulfonic acid (2R,3R,5R)-5-benzyloxymethyl-2-((1E,5E)-2,6,10-trimethyl-undeca-1,5,9-trienyl)-tetrahydro-furan-3-ylmethyl ester 
• 194720-04-2 (2R,3S,5R)-3-Benzenesulfonylmethyl-5-benzyloxymethyl-2-((1E,5E)-2,6,10-trimethyl-undeca-1,5,9-trienyl)-tetrahydro-furan 

Relevant academic research and scientific papers

Specific C-C Bond Construction by Remote C-H Activation: Synthesis of (-)-trans-Cembranolide

The first total synthesis of (-)-trans-cembranolide (1), isolated from Sinularia mayi Luttschw., is described. The key step in the synthesis is the diastereoselective Rh-mediated cyclization of the enantiomerically pure diazo ester 4 to the tetrahydrofuran 3a.