194785-94-9Relevant academic research and scientific papers
Enhanced RNA binding of dimerized aminoglycosides
Michael, Katja,Wang, Hai,Tor, Yitzhak
, p. 1361 - 1371 (2007/10/03)
Aminoglycoside antibiotics have recently emerged as an intriguing family of RNA binding molecules and they became leading structures for the design of novel RNA ligands. The demystification of the aminoglycoside-RNA recognition phenomenon is required for
Dimeric aminoglycosides: Design, synthesis and RNA binding
Wang, Hai,Tor, Yitzhak
, p. 1951 - 1956 (2007/10/03)
The design and synthesis of symmetrical and non-symmetrical dimeric aminoglycosides derived from kanamycin A, tobramycin, and neomycin B are described. The covalently-linked dimeric aminoglycosides show enhanced activity as ribozyme inhibitors when compared to their natural counterparts.
