19479-80-2

Basic information

• Product Name: 1-(diazomethyl)-4-nitrobenzene
• Synonyms: 1-(diazomethyl)-4-nitrobenzene;(4-Nitrophenyl)diazomethane;4-Nitrophenyldiazomethane;Einecs 243-098-2
• CAS NO: 19479-80-2
• Molecular Formula: C₇H₅N₃O₂
• Molecular Weight: 163.1335
• EINECS: 243-098-2
• Mol File: 19479-80-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: 1-(diazomethyl)-4-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(diazomethyl)-4-nitrobenzene(19479-80-2)
• EPA Substance Registry System: 1-(diazomethyl)-4-nitrobenzene(19479-80-2)

Safety Data

• Hazardous Substances Data: 19479-80-2(Hazardous Substances Data)

Usage

General Description

1-(diazomethyl)-4-nitrobenzene is a chemical compound with the molecular formula C8H6N4O2. It is a yellow crystalline solid that is commonly used as a reagent in organic synthesis. The compound contains a nitro group and a diazomethyl group, which are both important functional groups in organic chemistry. 1-(diazomethyl)-4-nitrobenzene is highly reactive and is often used in reactions to form new carbon-carbon bonds and to introduce the diazomethyl group into various organic molecules. Due to its reactivity, it should be handled with care and proper safety precautions.

InChI:InChI=1/C7H5N3O2/c8-9-5-6-1-3-7(4-2-6)10(11)12/h1-5H

Upstream product

• 1747-50-8 4-methyl-N'-[(4-nitrophenyl)methylidene]benzene-1-sulfonohydrazide 
• 555-16-8 4-nitrobenzaldehdye 
• 16286-94-5 C₁₆H₁₇N₃O₄S 
• 6310-10-7 4-nitrobenzaldehyde hydrazone 

Downstream Products

• 63927-17-3 4-{6-[(4-nitro-phenyl)-methanesulfonyl]-cyclohex-1-enyl}-morpholine 
• 99557-41-2 3-hydroxy-4-(4-nitrophenyl)quinolin-2(1H)-one 
• 78815-25-5 (6R)-phenylacetamido-2-methoxy-(5R)-penem-3-p-nitrobenzyl-carboxylate 
• 87996-92-7 (6R)-phenylacetamido-2-benzoyloxy-(5R)-penem-3-p-nitrobenzyl-carboxylate 
• 15330-76-4 1,3-bis-(4-nitrophenyl)-propan-2-one 
• 82820-05-1 C₁₅H₁₀N₄O₄ 
• 500-11-8 4-nitrobenzyl fluoride 
• 61860-62-6 C₇H₅⁽²⁾HFNO₂ 
• 6310-10-7 4-nitrobenzaldehyde hydrazone 
• 619-78-3 1-dichloromethyl-4-nitrobenzene 
• 29848-57-5 4-(difluoromethyl)nitrobenzene 
• 555-16-8 4-nitrobenzaldehdye 
• 23837-16-3 ((4-nitrophenyl)methylene)bis(phenylsulfane) 
• 219991-48-7 N-(4-nitrophenyl)-2-methyl-2-phenylaziridine 

Relevant articles and documents

Synthesis of Aryldihalomethanes by Denitrogenative Dihalogenation of Benzaldehyde Hydrazones

We report a denitrogenative dihalogenation reaction of phenyldiazomethanes in which the hypervalent iodine reagents PhICl2 and TolIF2 act as surrogates for elemental chlorine and fluorine. Halogen transfer from iodane to aryldiazomethane is described, as is a tandem oxidative dihalogenation reaction between iodane and hydrazone. This is the first use of non-α-stabilized diazo compounds in this reaction, which provided an efficient synthesis of aryldifluoromethane (ArCHF2) and aryldichloromethane (ArCHCl2) derivatives. (Figure presented.).

A Transition-Metal-Free and Base-Mediated Carbene Insertion into Sulfur-Sulfur and Selenium-Selenium Bonds: An Easy Access to Thio- and Selenoacetals

A transition-metal-free and base-mediated carbene insertion across sulfur-sulfur and selenium-selenium bonds has been developed by employing N-tosylhydrazone as a stable and safe carbene precursor. The ylide formation from carbene followed by Stevens rearrangement are considered to be the key steps. This thiol and selenol-free protocol delivers thioacetals and selenoacetals in good to excellent yields in short reaction time with good functional group tolerance. A one-pot synthesis involving in situ generation of tosylhydrazone has also been demonstrated. (Figure presented.).

Method for labeling and fragmenting DNA

The invention relates to a method for labeling and fragmenting a single- or double-stranded deoxyribonucleic acid (DNA) comprising the following steps: chemically fragmenting the DNA by creating at least one abasic site on said DNA, attaching a marker to at least one of the fragments by means of a labeling reagent, said reagent covalently and predominantly coupling to at least one phosphate of said fragment. The invention finds a preferred application in the field of diagnosis.