194809-95-5

Usage

Uses

Used in Pharmaceutical Industry:
(4-Naphthalen-2-yl-thiazol-2-yl)-acetonitrile is used as a key intermediate in the synthesis of new drugs due to its distinctive molecular structure. Its potential role in drug development lies in its ability to be incorporated into pharmaceutical compounds that target specific biological pathways or receptors, thereby offering novel therapeutic options for various diseases and conditions.
Used in Materials Science:
In the field of materials science, (4-Naphthalen-2-yl-thiazol-2-yl)-acetonitrile is utilized for the development of advanced materials with specialized functions. Its unique chemical structure allows it to contribute to the creation of materials with tailored properties, such as improved conductivity, stability, or responsiveness to environmental stimuli.
Further research and exploration of (4-Naphthalen-2-yl-thiazol-2-yl)-acetonitrile's properties and potential applications are essential to fully harness its benefits and understand its limitations. This will pave the way for its integration into innovative solutions across different industries.

Upstream product

• 7357-70-2 Cyanothioacetamide 
• 613-54-7 2-Bromo-2'-acetonaphthone 

Downstream Products

• 1198208-55-7 C₂₁H₁₅N₅S 

Relevant academic research and scientific papers

A novel approach to bis(1,3-azol-2-yl)acetonitriles and bis(1,3-azol-2-yl)methanes: Via the [3 + 2]-dipolar cycloaddition of imidazole N -oxides and 2-heteroaryl-3,3-dimethylacrylonitriles

A new synthetic approach for obtaining previously unknown bis(1,3-azol-2-yl)acetonitriles and bis(1,3-azol-2-yl)methanes has been developed. It is based on 1,3-dipolar cycloaddition between 2-unsubstituted imidazole N-oxides and 2-(1,3-azol-2-yl)-3,3-dimethylacrylonitriles, which are easily available through the condensation of (1,3-azol-2-yl)acetonitriles with acetone. The method allows for the construction of various unsymmetric derivatives based on imidazole, oxazole, thiazole, and 1,3,4-thiadiazole cyclic molecules. Its potential has been demonstrated via the synthesis of 24 diverse derivatives with yields of 29-92%. Bis(1,3-azol-2-yl)acetonitriles can be converted to the corresponding bis(1,3-azol-2-yl)methanes via simple acid hydrolysis followed by subsequent spontaneous decarboxylation at nearly quantitative yields.

A Convenient Synthesis of Thiophene,1,3-Thiazole,2,3-Dihydro-1,3,4-thiadiazole and Pyrazole Derivatives.

Thiazole 3 reacts with benzaldehyde, p-tolualdehyde, salicylaldehyde, benzenediazonium chloride and aryl isothiocyanates to afford 4a, 4b, 5, 9 and 10a, b, respectively. 10a reacted with a-haloesters, a-haloketones, chloroacetonitrile and hydrazonoyl halides to give aminothiophenes 13, 15, 16 and 2,3-dihydro-1,3,4-thiadiazoles 21, 27, respectively.Aminopyrazole 19 was prepared via reaction of S-methyl 18 with hydrazine hydrate.Substituted pyrazoles 29 were obtained through the reaction of hydrazonoyl halides and 2-oxosulfones 28 in ethanolic sodium ethoxide solution.. 2, 3-Dihydrothiadiazoles 33 were synthesised by the reaction of 28 with a mixture of aryl isothiocyanates and hydrazonoyl halides.All the structures were confirmed by elemental analyses and spectral data.