194853-80-0Relevant academic research and scientific papers
Synthesis of tetrahydroisoquinolines through TiCl4-mediated cyclization and Et3SiH reduction
Shi, Zeyu,Xiao, Qiong,Yin, Dali
, p. 729 - 732 (2019/10/02)
A versatile and efficient telescoped reaction sequence for the synthesis of tetrahydroisoquinolines (THIQs) is reported that uses TiCl4 to promote cyclization of a benzylaminoacetal derivative and Et3SiH for reduction of the intermediate 4-hydroxy-THIQ. This method is complimentary to the classical Pomeranz-Fritsch and related reactions since it tolerates electron-withdrawing substituents and allows access to 8-substituted THIQs.
Aminoheterocyclic derivatives as antithrombotic or anticoagulant agents
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, (2008/06/13)
Compounds of formula (I), wherein G1 is CH or N; G2 is CH or N; R1 is a variety of optional substituents, L1 is (1-4C)alkylene; T1 is CH or N; R2 and R3 are independently hydroge
