194856-33-2

Upstream product

• 194856-29-6 5-Acetyl-2-methyl-4-nitro-6-(2-nitro-phenyl)-2H-pyridazin-3-one 
• 194856-24-1 3,6-Dimethyl-4-(o-nitrophenyl)isoxazolo[3,4-d]pyridazin-7(6H)-one 
• 25506-00-7 3,6-dimethyl-4-phenyl isoxazolo<3,4-d>pyridazin-7(6H)-one 

Relevant academic research and scientific papers

New synthesis of differently fused pyridazinoquinolines

Treatment of properly 6-(substituted aryl)-5-acetyl-4-chloro- and 4- methylthio-3(2H)-pyridazinones with SnCl2/HCl afforded pyridazino[4,3-c] quinolinones 9 and 10, whereas the pyridazino[4,5-b] quinolinone derivative 6 was prepared by reductio

Synthesis of 4,5-functionalized-2-methyl-6-(substituted aryl)-3(2H)- pyridazinones: A new group of potent platelet aggregation inhibitors

A series of 4,5-functionalized-2-methyl-6-(substituted phenyl)-3(2H)- pyridazinones were synthesized and evaluated as platelet aggregation inhibitors in human platelet plasma (PRP). The new products generally displayed significant higher activity with respect to the corresponding unsubstituted aryl compounds. Compounds 27 and 31 appeared of particular interest, being their IC(50s) in the submicromolar range. Structure-activity relationships (SARs) are discussed.