194874-02-7

Usage

Uses

Used in Pharmaceutical Industry:
1-(3-Nitrophenyl)-3-(trifluoroMethyl)benzene is used as a building block for the synthesis of various organic compounds, contributing to the development of new drugs. The presence of the trifluoromethyl group in 1-(3-Nitrophenyl)-3-(trifluoroMethyl)benzene is known to increase the biological activity of pharmaceuticals, making it a crucial component in drug discovery and development.
Used in Chemical Industry:
In the chemical industry, 1-(3-Nitrophenyl)-3-(trifluoroMethyl)benzene is utilized as an intermediate in the production of different organic compounds. Its unique structure and properties make it a valuable asset in the synthesis of a wide range of chemical products.

Upstream product

• 585-79-5 m-nitrobromobenzene 
• 1423-26-3 (meta-(trifluoromethyl)phenyl)boronic acid 

Relevant academic research and scientific papers

Development of a continuous-flow system for catalysis with palladium(0) particles

Heterogeneous catalysis for organic synthesis under continuous-flow conditions becomes possible by a new reactor-based approach. Continuous-flow reactors with a monolithic glass/polymer composite interior are loaded with palladium particles by ion exchange followed by reduction. When incorporated into a continuous-flow setup (PASSflow) this reactor allows the transfer-hydrogenation of alkenes, alkynes, nitro-substituted aromatic compounds and benzyl ethers in the flow-through mode. In addition, the activity of the catalysts is well suited to achieve Suzuki, Sonogashira and Heck cross-coupling reactions in the absence of phosphanes or any other ligands, resulting in a greatly simplified purification. As an extension to this concept a bifunctional support was prepared inside the reactor consisting of Pd particles and an ion-exchange group (hydroxide form). In the Suzuki-Miyaura reaction the reactor serves as a base for immobilisation and activation of the boronic acid as boronate and as a catalyst for promoting the C-C coupling reaction under continuous-flow conditions. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

Highly Efficient Palladium-Catalyzed Boronic Acid Coupling Reactions in Water: Scope and Limitations

The "ligandless" palladium acetate-catalyzed Suzuki cross-coupling reaction of ArX with aryl- and vinylboronic acids in water without organic cosolvent in the presence of tetrabutylammonium bromide is reported. Aryl bromides give high yields and considerably accelerate the coupling. A wide variety of functional groups can be tolerated. Aryl iodides, however, give incomplete conversion and aryl triflate coupling shows no improvement over reported conditions.