1949-20-8 Usage
Uses
Used in Pharmaceutical Industry:
5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT is used as an anti-inflammatory agent for its ability to reduce inflammation and alleviate pain. Its molecular structure allows it to interact with specific biological targets, making it a potential candidate for the development of new anti-inflammatory drugs.
Used in Anticancer Applications:
In the field of oncology, 5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT may be employed as a potential anticancer agent. Its specific molecular interactions could potentially modulate oncological signaling pathways, leading to the inhibition of tumor growth and progression.
Used in Drug Delivery Systems:
5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT can also be utilized in the development of novel drug delivery systems. Its unique properties may allow for improved delivery, bioavailability, and therapeutic outcomes when combined with various organic and metallic nanoparticles as carriers.
Used in Cough Suppressant Formulations:
As an anti-inflammatory drug, 5-[2-(DIETHYLAMINO)ETHYL]-3-PHENYL-1,2,4-OXADIAZOLE CITRATE SALT is used as a cough suppressant, particularly in the form of Oxolamine Citrate. Its anti-inflammatory properties help to reduce the irritation and inflammation in the respiratory tract, providing relief from coughing.
Originator
Bredon,Organon
Manufacturing Process
18.7 g 3-chloro-propionyl chloride in 50 ml of dry ether was added dropwise with stirring to the cooled with ice solution 40 g of N-hydroxybenzamidine in 450 ml dry ester. A dense precipitate had fallen. The mixture was stirred 0.5 hour at room temperature and then was filtered off. The precipitate was thoroughly washed with water for a removal hydrochloride of starting Nhydroxybenzamidine whereas N-(amino)phenylmethylene-3-Cl-propionamide didnt solve. It was dried in vacuum over P2O5. Yield of clean product 94% from theoretical. MP: 98°-99°C. The solution of 9.2 g diethyl amine in 50 ml dry benzene was added dropwise to a suspension of above prepared N(amino)phenylmethylene-3-Cl-propionamide in dry benzene with stirring and cooling.
The mixture was warmed and stirred else 2 hours after adding. Then it was cooled, washed two times with water and dried over CaCl2. Then the solvent was removed. The residue was distilled in vacuum. Diethyl-[2-(3phenyl[1,2,4]oxadiasol-5)ethyl]amine (oxolamine) had BP: 127°C/0.4 mm. Yield 10.5 g.
Therapeutic Function
Antitussive, Antiinflammatory
Safety Profile
Poison by intraperitoneal route. Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits toxic fumes of NOx. See also AMINES and other oxolamhe entries
Check Digit Verification of cas no
The CAS Registry Mumber 1949-20-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,9,4 and 9 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1949-20:
(6*1)+(5*9)+(4*4)+(3*9)+(2*2)+(1*0)=98
98 % 10 = 8
So 1949-20-8 is a valid CAS Registry Number.
InChI:InChI=1/C14H19N3O.C6H8O7/c1-3-17(4-2)11-10-13-15-14(16-18-13)12-8-6-5-7-9-12;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-9H,3-4,10-11H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
