19491-02-2Relevant academic research and scientific papers
Atropo-enantioselective synthesis of the natural bicoumarin (+)-yisokotanin A via a configurationally stable biaryl lactone
Bringmann, Gerhard,Hinrichs, Juergen,Henschel, Petra,Kraus, Juergen,Peters, Karl,Peters, Eva-Maria
, p. 1096 - 1106 (2002)
The atropo-enantioselective total synthesis of the axially chiral bicoumarin (+)-isokotanin A (1) is described. Key steps were the formation of a configurationally stable seven-membered biaryl lactone and its kinetic resolution by atroposelective ring cleavage. The previous assignment of the absolute configuration of (+)-isokotanin A (1) (and its synthetic precursors) was confirmed by quantum chemical CD calculations. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.
