194918-44-0Relevant academic research and scientific papers
6-Thio-2'-deoxyinosine: Synthesis, incorporation, and evaluation as a postsynthetically modifiable base in oligonucleotides
Coleman, Robert S.,Arthur, John C.,McCary, Jason L.
, p. 11191 - 11202 (1997)
The synthesis of 6-thio-2'-deoxyinosine (d(S6)I) in a form suitably protected for solid-phase oligonucleotide synthesis is reported. This thionucleic acid was incorporated in high yield into short oligodeoxynucleotides, and the thiocarbonyl group could be
Site-specific Disulfide Bridges in Oligodeoxyribonucleotide Duplexes containing 6-Mercaptopurine and 4-Thiothymine bases
Milton, John,Connolly, Bernard A.,Nikiforov, Theo T.,Cosstick, Richard
, p. 779 - 780 (1993)
A self complementary oligodeoxynucleotide duplex containing 6-thio-2'-deoxyinosine and 4-thio-2'-deoxythymidine undergoes cross-linking to form interstrand disulfide bridges uner aerobic conditions; the reaction is reversed by dithiothreitol.
